N-(5-(3-acetyl-1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-2-yl)acetamide

Base Information

Chemical Name:N-(5-(3-acetyl-1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-2-yl)acetamide
CAS No.:1201645-37-5
Molecular Formula:C₂₉H₂₄N₆O₂
Molecular Weight:488.549
Hs Code.:

Synonyms:N-(5-(3-acetyl-1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-2-yl)acetamide

Suppliers and Price of N-(5-(3-acetyl-1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-2-yl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(5-(3-acetyl-1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-2-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(5-(3-acetyl-1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-2-yl)acetamide

There total 13 articles about N-(5-(3-acetyl-1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1201645-36-4
N-(5-(4-(4-(2-cyanopropan-2-yl)benzyl)-3-aminoquinolin-6-yl)pyridin-2-yl)acetamide

: 108-24-7
acetic anhydride

: 1201645-37-5
N-(5-(3-acetyl-1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-2-yl)acetamide

Guidance literature:: N-(5-(4-(4-(2-cyanopropan-2-yl)benzyl)-3-aminoquinolin-6-yl)pyridin-2-yl)acetamide; acetic anhydride; With potassium acetate; In toluene; at 20 ℃; for 2h;

With tert.-butylnitrite; In toluene; at 80 ℃;

Reference yield:

: 129488-74-0
4-(1-cyano-1-methylethyl)benzoic acid

: 1201645-37-5
N-(5-(3-acetyl-1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

2.2: 25 °C

3.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

4.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

5.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

6.1: hydrogenchloride / acetone / 24 h

7.1: hydrogenchloride / water / 24 h

8.1: potassium acetate / ethanol / 5 h / Reflux

9.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 8 h / Inert atmosphere; Reflux

10.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 12 h / Inert atmosphere; Reflux

11.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2 h

12.1: potassium acetate / toluene / 2 h / 20 °C

12.2: 80 °C

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; oxalyl dichloride; hydrogen; potassium acetate; sodium carbonate; caesium carbonate; ozone; N,N-dimethyl-formamide; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; 10.1: Suzuki Coupling;

Reference yield:

: 1201643-78-8
2-(4-(5-bromo-1-tosyl-1H-indol-3-carbonyl)phenyl)-2-methylpropanenitrile

: 1201645-37-5
N-(5-(3-acetyl-1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

2.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

3.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

4.1: hydrogenchloride / acetone / 24 h

5.1: hydrogenchloride / water / 24 h

6.1: potassium acetate / ethanol / 5 h / Reflux

7.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 8 h / Inert atmosphere; Reflux

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 12 h / Inert atmosphere; Reflux

9.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2 h

10.1: potassium acetate / toluene / 2 h / 20 °C

10.2: 80 °C

With hydrogenchloride; sodium tetrahydroborate; hydrogen; potassium acetate; sodium carbonate; caesium carbonate; ozone; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; 8.1: Suzuki Coupling;