17-hydroxy-20-oxopregn-5-en-3β-yl p-toluenusulfonate

Base Information

• Chemical Name: 17-hydroxy-20-oxopregn-5-en-3β-yl p-toluenusulfonate
• CAS No.: 17291-60-0
• Molecular Formula: C₂₈H₃₈O₅S
• Molecular Weight: 486.673
• Mol file: 17291-60-0.mol

Synonyms:17-hydroxy-20-oxopregn-5-en-3β-yl p-toluenusulfonate

Chemical Property of 17-hydroxy-20-oxopregn-5-en-3β-yl p-toluenusulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17-hydroxy-20-oxopregn-5-en-3β-yl p-toluenusulfonate

There total 8 articles about 17-hydroxy-20-oxopregn-5-en-3β-yl p-toluenusulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

17-Hydroxypregnenolone (387-79-1) + p-toluenesulfonyl chloride (98-59-9) → 17-hydroxy-20-oxopregn-5-en-3β-yl p-toluenusulfonate (17291-60-0)

Guidance literature:

In pyridine; at 20 ℃; for 23h;

Reference yield:

Acetic acid (3S,8R,9S,10R,13S,14S,17R)-17-acetyl-16-bromo-17-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (114417-72-0) → 17-hydroxy-20-oxopregn-5-en-3β-yl p-toluenusulfonate (17291-60-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / ammonium acetate, hydrogen / 5percent Pd/C / methanol / 2 h

2: 83 percent / potasium carbonate / methanol / 1 h / Heating

3: 82 percent / pyridine / 23 h / 20 °C

With ammonium acetate; hydrogen; potassium carbonate; palladium on activated charcoal; In pyridine; methanol;

Reference yield:

3β-acetoxy-17α-hydroxy-5-pregnen-20-one (1863-39-4) → 17-hydroxy-20-oxopregn-5-en-3β-yl p-toluenusulfonate (17291-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / potasium carbonate / methanol / 1 h / Heating

2: 82 percent / pyridine / 23 h / 20 °C

With potassium carbonate; In pyridine; methanol;

upstream raw materials:

17-Hydroxypregnenolone

p-toluenesulfonyl chloride

3β-acetoxy-17α-hydroxy-5-pregnen-20-one

20,20-ethanediyldioxy-pregn-5-ene-3β,17-diol

Downstream raw materials:

17-hydroxy-3β-triphenylmethoxy-20-oxopregn-5-en-11α-yl hydrogen butanedioate

11α,17-dihydroxy-3β-triphenylmethoxypregn-5-en-20-one