Benzyl (S)-2-<-2-phenylethyl>phosphoryl>oxy>-3-methylbutanoate

Base Information

Chemical Name:Benzyl (S)-2-<-2-phenylethyl>phosphoryl>oxy>-3-methylbutanoate
CAS No.:153465-22-6
Molecular Formula:C₂₉H₃₄NO₇P
Molecular Weight:539.565
Hs Code.:

Benzyl (S)-2-<<methoxy<(R)-1-<(benzyloxycarbonyl)amino>-2-phenylethyl>phosphoryl>oxy>-3-methylbutanoate

Synonyms:Benzyl (S)-2-<-2-phenylethyl>phosphoryl>oxy>-3-methylbutanoate

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Chemical Property of Benzyl (S)-2-<-2-phenylethyl>phosphoryl>oxy>-3-methylbutanoate

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Technology Process of Benzyl (S)-2-<-2-phenylethyl>phosphoryl>oxy>-3-methylbutanoate

There total 3 articles about Benzyl (S)-2-<-2-phenylethyl>phosphoryl>oxy>-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 65138-05-8
(S)-2-hydroxy-3-methylbutyric acid benzyl ester

: 107133-12-0
methyl hydrogen <<1(R)-1-N-<(phenylmethoxy)carbonyl>amino>-2-phenylethyl>phosphonate

: 153465-22-6
Benzyl (S)-2-<-2-phenylethyl>phosphoryl>oxy>-3-methylbutanoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h; Ambient temperature;
DOI:10.1021/jo00121a045

Reference yield:

: C₁₇H₂₀NO₄P

: 153465-22-6
Benzyl (S)-2-<-2-phenylethyl>phosphoryl>oxy>-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaIO₄ / dioxane / 16 h / Ambient temperature

2: 85 percent / DIEA, BOP / dimethylformamide / 2 h / Ambient temperature

With sodium periodate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a045

Reference yield:

: (R)-<1-<(Benzyloxycarbonyl)amino>-2-phenylethyl>phosphonous acid

: 153465-22-6
Benzyl (S)-2-<-2-phenylethyl>phosphoryl>oxy>-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: DCC, DMAP / tetrahydrofuran / 24 h / Ambient temperature

2: aq. NaIO₄ / dioxane / 16 h / Ambient temperature

3: 85 percent / DIEA, BOP / dimethylformamide / 2 h / Ambient temperature

With dmap; sodium periodate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a045