¹⁴C-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Base Information

• Chemical Name: ¹⁴C-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
• CAS No.: 917358-52-2
• Molecular Formula: C₂₉H₃₁N₇O
• Molecular Weight: 495.6
• Mol file: 917358-52-2.mol

Synonyms:¹⁴C-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Chemical Property of ¹⁴C-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ¹⁴C-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

There total 6 articles about ¹⁴C-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) + 4-chloromethyl-N-(4-methyl-3-[4-(1-oxy-pyridin-3-yl)-[2-(14)C]pyrimidin-2-ylamino]-phenyl)-benzamide hydrochloride (917358-62-4) → 14C-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide (917358-52-2)

Guidance literature:

1-methyl-piperazine; 4-chloromethyl-N-(4-methyl-3-[4-(1-oxy-pyridin-3-yl)-[2-⁽¹⁴⁾C]pyrimidin-2-ylamino]-phenyl)-benzamide hydrochloride; In ethanol; at 45 ℃; for 5h;

With sodium hydroxide; water; In ethanol; at 20 - 90 ℃; for 0.5h;

Reference yield:

N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)-methyl)benzamide (581076-59-7) + 14C-4-(Pyridin-3-yl)pyrimidin-2-amine → 14C-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide (917358-52-2)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 4h; Temperature;

DOI:10.1002/jlcr.3830

Reference yield:

methyl 4-formylbenzoate (1571-08-0) → 14C-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide (917358-52-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 °C

2: potassium tert-butylate / tetrahydrofuran / 17 h / 20 °C / Inert atmosphere

3: sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 5,5-dimethyl-1,3-cyclohexadiene / 4 h / 140 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium tert-butylate; sodium tris(acetoxy)borohydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane;

DOI:10.1002/jlcr.3830

upstream raw materials:

1-methyl-piperazine

4-chloromethyl-N-(4-methyl-3-[4-(1-oxy-pyridin-3-yl)-[2-⁽¹⁴⁾C]pyrimidin-2-ylamino]-phenyl)-benzamide hydrochloride

N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)-methyl)benzamide

methyl 4-formylbenzoate

Downstream raw materials:

4-(4-methyl-4-oxy-piperazin-1-yl)methyl-N-[4-methyl-3-(4-pyridin-3-yl-[2-⁽¹⁴⁾C]pyrimidin-2-ylamino)-phenyl]-benzamide

4-(4-methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-[2-⁽¹⁴⁾C]pyrimidin-2-ylamino)-phenyl]-benzamide mesylate