(1S,3R,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,6,7-trihydroxy-3-(1-methyl-1H-tetrazol-5-yl)-2,8-dioxa-bicyclo[3.2.1]octane-4,5-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:(1S,3R,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,6,7-trihydroxy-3-(1-methyl-1H-tetrazol-5-yl)-2,8-dioxa-bicyclo[3.2.1]octane-4,5-dicarboxylic acid dimethyl ester
CAS No.:152997-66-5
Molecular Formula:C₂₈H₃₆N₄O₁₁
Molecular Weight:604.614
Hs Code.:

(1S,3R,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,6,7-trihydroxy-3-(1-methyl-1H-tetrazol-5-yl)-2,8-dioxa-bicyclo[3.2.1]octane-4,5-dicarboxylic acid dimethyl ester

Synonyms:(1S,3R,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,6,7-trihydroxy-3-(1-methyl-1H-tetrazol-5-yl)-2,8-dioxa-bicyclo[3.2.1]octane-4,5-dicarboxylic acid dimethyl ester

Suppliers and Price of (1S,3R,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,6,7-trihydroxy-3-(1-methyl-1H-tetrazol-5-yl)-2,8-dioxa-bicyclo[3.2.1]octane-4,5-dicarboxylic acid dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,3R,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,6,7-trihydroxy-3-(1-methyl-1H-tetrazol-5-yl)-2,8-dioxa-bicyclo[3.2.1]octane-4,5-dicarboxylic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,3R,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,6,7-trihydroxy-3-(1-methyl-1H-tetrazol-5-yl)-2,8-dioxa-bicyclo[3.2.1]octane-4,5-dicarboxylic acid dimethyl ester

There total 6 articles about (1S,3R,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,6,7-trihydroxy-3-(1-methyl-1H-tetrazol-5-yl)-2,8-dioxa-bicyclo[3.2.1]octane-4,5-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: <1S-<1α(4R*,5S*),3α,4β,5α,6α(2E,4R*,6R*),7β>>-1-<4-(acetyloxy)-5-methyl-3-methylene-6-phenylhexyl>-3-(1-methyl-1H-tetrazol-5-yl)-4,6,7-trihydroxy-2,8-dioxabicyclo<3.2.1>octane-4,5-dicarboxylic acid, 6-(4,6-dimethyl-2-octenoate), 4,5-dimethyl...

: 152997-66-5
(1S,3R,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,6,7-trihydroxy-3-(1-methyl-1H-tetrazol-5-yl)-2,8-dioxa-bicyclo[3.2.1]octane-4,5-dicarboxylic acid dimethyl ester

Guidance literature:: With N-methylhydroxyamine hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 21 ℃; for 18h;
DOI:10.1021/jm00018a010

Reference yield:

: 142561-97-5
zaragozic acid A trimethyl ester

: 152997-66-5
(1S,3R,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,6,7-trihydroxy-3-(1-methyl-1H-tetrazol-5-yl)-2,8-dioxa-bicyclo[3.2.1]octane-4,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: aq. NaOH / tetrahydrofuran / 21 h

2: 1.) oxalyl chloride, 3.) NH₃ / 1.) CH₂Cl₂, 0 deg C, 5 min, 2.) CH₂Cl₂, THF, acetonitrile, a) 0 deg C, 2 h, b) 21 deg C, 2 h

3: 85 percent / triethylamine, trifluoroacetic anhydride / CH₂Cl₂ / 5 h / 21 °C

4: NaN₃, Et₃N*HCl / dimethylformamide / 2 h / 120 °C

5: NaHCO₃ / dimethylformamide / 16 h

6: N-methylhydroxylamine hydrochloride, triethylamine / dimethylformamide / 18 h / 21 °C

With sodium hydroxide; sodium azide; oxalyl dichloride; N-methylhydroxyamine hydrochloride; ammonia; triethylamine hydrochloride; sodium hydrogencarbonate; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00018a010

Reference yield:

: 144548-73-2
<1S-<1α-(4R*,5S*),3α,4β,5α,6α(2E,4R*,6R*),7β>>-1-<4-(acetyloxy)-5-methyl-3-methylene-6-phenylhexyl>-4,6,7-trihydroxy-2,8-dioxabicyclo<3.2.1>octane-3,4,5-tricarboxylic acid, 6-(4,6-dimethyl-6-octenoate), 4,5-dimethyl ester

: 152997-66-5
(1S,3R,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,6,7-trihydroxy-3-(1-methyl-1H-tetrazol-5-yl)-2,8-dioxa-bicyclo[3.2.1]octane-4,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) oxalyl chloride, 3.) NH₃ / 1.) CH₂Cl₂, 0 deg C, 5 min, 2.) CH₂Cl₂, THF, acetonitrile, a) 0 deg C, 2 h, b) 21 deg C, 2 h

2: 85 percent / triethylamine, trifluoroacetic anhydride / CH₂Cl₂ / 5 h / 21 °C

3: NaN₃, Et₃N*HCl / dimethylformamide / 2 h / 120 °C

4: NaHCO₃ / dimethylformamide / 16 h

5: N-methylhydroxylamine hydrochloride, triethylamine / dimethylformamide / 18 h / 21 °C

With sodium azide; oxalyl dichloride; N-methylhydroxyamine hydrochloride; ammonia; triethylamine hydrochloride; sodium hydrogencarbonate; triethylamine; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00018a010