2-amino-3-phenylbenzoic acid

Base Information

• Chemical Name: 2-amino-3-phenylbenzoic acid
• CAS No.: 4445-39-0
• Molecular Formula: C₁₃H₁₁NO₂
• Molecular Weight: 213.236
• Mol file: 4445-39-0.mol

Synonyms:2-amino-3-phenylbenzoic acid

Chemical Property of 2-amino-3-phenylbenzoic acid

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-3-phenylbenzoic acid

There total 1 articles about 2-amino-3-phenylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-chloroanthranilate (77820-58-7) → 2-amino-3-phenylbenzoic acid (4445-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / KF / Cl[(2-norbornyl)2PH](2'-Me₂N-1,1'-biphenyl)Pd(II) / dioxane / 110 °C

2: 97 percent / LiOH / methanol; tetrahydrofuran; H₂O

With potassium fluoride; lithium hydroxide; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1: Suzuki cross-coupling reaction;

DOI:10.1016/j.tetlet.2005.01.125

Reference yield: 29.0%

furan (110-00-9) + 2-amino-3-phenylbenzoic acid (4445-39-0) → 5-phenyl-1,4-dihydro-1,4-epoxynaphthalene (136131-40-3)

Guidance literature:

With isopentyl nitrite; In tetrahydrofuran; dichloromethane; for 1.5h; Heating;

DOI:10.1021/jo00023a041

Reference yield: 21.0%

(2S,6R)-2,6-dimethyl-4-(5-aminopyridin-2-yl)morpholine (956699-06-2) + 2-amino-3-phenylbenzoic acid (4445-39-0) → 3-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-8-phenylquinazolin-4(3H)-one

Guidance literature:

With trimethyl orthoformate; In tetrahydrofuran; at 110 ℃; for 18h; Sealed tube;

DOI:10.1016/j.ejmech.2016.10.040

upstream raw materials:

methyl 3-chloroanthranilate

Downstream raw materials:

5-phenyl-1,4-dihydro-1,4-epoxynaphthalene

2-benzyl-8-phenyl-1-naphthol

2-benzyl-5-phenyl-1-naphthol

5-phenyl-1-naphthol