2-benzyl-1-methylene-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 2-benzyl-1-methylene-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1220992-87-9
• Molecular Formula: C₁₇H₁₇N
• Molecular Weight: 235.329
• Mol file: 1220992-87-9.mol

Synonyms:2-benzyl-1-methylene-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 2-benzyl-1-methylene-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-benzyl-1-methylene-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about 2-benzyl-1-methylene-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

N-benzyl-N-(2-phenylethyl)acetamide (100835-73-2) → 2-benzyl-1-methylene-1,2,3,4-tetrahydroisoquinoline (1220992-87-9)

Guidance literature:

With phosphorus pentoxide; In 5,5-dimethyl-1,3-cyclohexadiene; Heating; Inert atmosphere;

DOI:10.1002/adsc.200900602

Reference yield: 39.0%

2-benzyl-1-methylene-1,2,3,4-tetrahydroisoquinoline (1220992-87-9) + Dimethylphenylsilane (766-77-8) → N-benzyl-1-methyl-1,2,3,4-tetrahydroisoquinoline + N-benzyl-1-[(dimethyl(phenyl)silyl)methyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:

With tris(pentafluorophenyl)borate; In chlorobenzene; at 20 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jacs.0c05241

Reference yield:

2-benzyl-1-methylene-1,2,3,4-tetrahydroisoquinoline (1220992-87-9) → (+)-2-benzyl-1-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (Sa,R,R)-SIPHOS-PE; hydrogen; iodine; In tetrahydrofuran; at 0 ℃; for 10h; under 760.051 Torr; enantioselective reaction;

DOI:10.1002/adsc.200900602

upstream raw materials:

N-benzyl-N-(2-phenylethyl)acetamide