N-(2-[7-(2-methoxyphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide

Base Information

Chemical Name:N-(2-[7-(2-methoxyphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide
CAS No.:1287785-20-9
Molecular Formula:C₂₂H₂₃NO₃
Molecular Weight:349.43
Hs Code.:

Synonyms:N-(2-[7-(2-methoxyphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide

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Chemical Property of N-(2-[7-(2-methoxyphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide

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Technology Process of N-(2-[7-(2-methoxyphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide

There total 6 articles about N-(2-[7-(2-methoxyphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1287785-11-8
N-[2-(7-bromo-1,6-dihydro-2H-indeno[5,4-b]furan-8-yl)-ethyl]acetamide

: 5720-06-9
2-Methoxyphenylboronic acid

: 1287785-20-9
N-(2-[7-(2-methoxyphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 80 ℃; for 0.5h;
DOI:10.1021/jm200221q

Reference yield:

: 221530-44-5
2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile

: 1287785-20-9
N-(2-[7-(2-methoxyphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia; hydrogen / ethanol / 72 h / 20 °C

2: hydrogenchloride / methanol; ethyl acetate / 3 h / 60 °C

3: triethylamine / dichloromethane / 0.17 h / 20 °C

4: bromine / dichloromethane / 0.5 h / 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 0.5 h / 80 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; hydrogen; bromine; sodium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water; ethyl acetate; toluene; 5: Suzuki coupling;
DOI:10.1021/jm200221q

Reference yield:

: 2-(1,6-dihydro-2H-indeno[5,4-b]furan-8-yl)ethylamine hydrochloride

: 1287785-20-9
N-(2-[7-(2-methoxyphenyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.17 h / 20 °C

2: bromine / dichloromethane / 0.5 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 0.5 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; triethylamine; In ethanol; dichloromethane; water; toluene; 3: Suzuki coupling;
DOI:10.1021/jm200221q