tert-butyl amino>ethanoate

Base Information

• Chemical Name: tert-butyl amino>ethanoate
• CAS No.: 123642-59-1
• Molecular Formula: C₁₆H₂₄N₂O₆
• Molecular Weight: 340.376
• Mol file: 123642-59-1.mol

Synonyms:tert-butyl amino>ethanoate

Chemical Property of tert-butyl amino>ethanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl amino>ethanoate

There total 3 articles about tert-butyl amino>ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

tert-Butyl chloroacetate (107-59-5) + <1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl>amine (123642-58-0) → tert-butyl amino>ethanoate (123642-59-1)

Guidance literature:

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In acetonitrile; at 60 ℃; for 15h;

DOI:10.1021/jo00292a038

Reference yield:

4',5'-dimethoxy-2'-nitroacetophenone (4101-32-0) → tert-butyl amino>ethanoate (123642-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 23.6 percent / NH₄OAc, NaBH₃CN / methanol / 1) r.t, 4 days 2) 60 deg C, 24h

2: 39 percent / N,N,N',N'-tetramethyl-1,8-napthalenediamine / acetonitrile / 15 h / 60 °C

With ammonium acetate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium cyanoborohydride; In methanol; acetonitrile;

DOI:10.1021/jo00292a038

Reference yield:

1-(3,4-dimethoxyphenyl)ethanone (1131-62-0) → tert-butyl amino>ethanoate (123642-59-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / HNO₃ conc. / 1 h / 18 - 22 °C

2: 23.6 percent / NH₄OAc, NaBH₃CN / methanol / 1) r.t, 4 days 2) 60 deg C, 24h

3: 39 percent / N,N,N',N'-tetramethyl-1,8-napthalenediamine / acetonitrile / 15 h / 60 °C

With ammonium acetate; nitric acid; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium cyanoborohydride; In methanol; acetonitrile;

DOI:10.1021/jo00292a038

upstream raw materials:

tert-Butyl chloroacetate

<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl>amine

4',5'-dimethoxy-2'-nitroacetophenone

1-(3,4-dimethoxyphenyl)ethanone

Downstream raw materials:

amino>ethanoic acid hydrochloride