1α-(3-Methylphenyl)-1,2,2-trimethylcyclopentane

Base Information

• Chemical Name: 1α-(3-Methylphenyl)-1,2,2-trimethylcyclopentane
• CAS No.: 80322-46-9
• Molecular Formula: C15H22
• Molecular Weight: 202.34
• Mol file: 80322-46-9.mol

Synonyms:

Chemical Property of 1α-(3-Methylphenyl)-1,2,2-trimethylcyclopentane

Chemical Property:

• PSA: 0.00000
• LogP: 4.46280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1α-(3-Methylphenyl)-1,2,2-trimethylcyclopentane

There total 19 articles about 1α-(3-Methylphenyl)-1,2,2-trimethylcyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C15H20 → (-)-herbertene (80322-46-9)

Guidance literature:

With platinum(IV) oxide; hydrogen; acetic acid; at 40 ℃; for 4h; under 760.051 Torr;

DOI:10.1002/anie.201907115

Reference yield: 80.0%

4-Benzyloxy-1-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-cyclohex-2-enol (220489-32-7) → (-)-herbertene (80322-46-9)

Guidance literature:

With camphor-10-sulfonic acid; In dichloromethane; Ambient temperature;

DOI:10.1021/jo982020d

Reference yield: 80.0%

benzyl 4-methylene-2-<(1S)-1,2,2-trimethylcyclopentyl>-2-cyclohexenyl-ether (220489-26-9) → (-)-herbertene (80322-46-9)

Guidance literature:

With camphor-10-sulfonic acid; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jo982020d

upstream raw materials:

3-bromoherbertene

4-Benzyloxy-1-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-cyclohex-2-enol

benzyl 4-methylene-2-<(1S)-1,2,2-trimethylcyclopentyl>-2-cyclohexenyl-ether

(-)-2,2,6-trimethyl-7-oxabicyclo[4.1.0]heptane-1-methanol

Downstream raw materials:

(-)-β-herbertenol O-acetate

(-)-β-bromoherbertenol

(-)-β-herbertenol

12-bromoherbertene

Refernces

• 1、 Abad, Antonio,Agullo, Consuelo,Cunat, Ana C.,Perni, Remedios H.. "Enantioselective synthesis of herbertane sesquiterpenes. Synthesis of (-)-herbertene and (-)-α-herbertenol". . p. 1741 - 1744. Retrieved 2007/10/03.
• 2、 Matsua, Akihiko,Yuki, Shunji,Nakayama, Mitsuru. "Structures of ent-Herbertane Sesquiterpenoids displaying Antifungal Properties from the Liverwort Herberta adunca". . p. 701 - 710. Retrieved 2007/10/02.