(Z)-2-(4-fluorophenyl)-1-(4-methoxyphenyl)-4-phenylbut-1-en-3-yn-1-yl acetate

Base Information

Chemical Name:(Z)-2-(4-fluorophenyl)-1-(4-methoxyphenyl)-4-phenylbut-1-en-3-yn-1-yl acetate
CAS No.:1370552-70-7
Molecular Formula:C₂₅H₁₉FO₃
Molecular Weight:386.422
Hs Code.:

Synonyms:(Z)-2-(4-fluorophenyl)-1-(4-methoxyphenyl)-4-phenylbut-1-en-3-yn-1-yl acetate

Suppliers and Price of (Z)-2-(4-fluorophenyl)-1-(4-methoxyphenyl)-4-phenylbut-1-en-3-yn-1-yl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-2-(4-fluorophenyl)-1-(4-methoxyphenyl)-4-phenylbut-1-en-3-yn-1-yl acetate

Chemical Property:

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Technology Process of (Z)-2-(4-fluorophenyl)-1-(4-methoxyphenyl)-4-phenylbut-1-en-3-yn-1-yl acetate

There total 2 articles about (Z)-2-(4-fluorophenyl)-1-(4-methoxyphenyl)-4-phenylbut-1-en-3-yn-1-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64583-16-0
1-fluoro-4-[2-(4-methoxyphenyl)ethynyl]benzene

: 1370552-70-7
(Z)-2-(4-fluorophenyl)-1-(4-methoxyphenyl)-4-phenylbut-1-en-3-yn-1-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: N-iodo-succinimide

2: copper(l) iodide; palladium diacetate; triethylamine; triphenylphosphine / 50 °C / Inert atmosphere

With N-iodo-succinimide; copper(l) iodide; palladium diacetate; triethylamine; triphenylphosphine; 2: Sonogashira coupling;
DOI:10.1021/jo300251c

Reference yield:

: 1337541-94-2
(Z)-2-(4-fluorophenyl)-2-iodo-1-(4-methoxyphenyl)vinyl acetate

: 536-74-3
phenylacetylene

: 1370552-70-7
(Z)-2-(4-fluorophenyl)-1-(4-methoxyphenyl)-4-phenylbut-1-en-3-yn-1-yl acetate

: 1370552-89-8
(E)-2-(4-fluorophenyl)-1-(4-methoxyphenyl)-4-phenylbut-1-en-3-yn-1-yl acetate

Guidance literature:: With copper(l) iodide; palladium diacetate; triethylamine; triphenylphosphine; at 50 ℃; optical yield given as %de; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jo300251c