Benzoic acid (2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:Benzoic acid (2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester
CAS No.:133776-32-6
Molecular Formula:C₂₄H₁₉FN₈O₄
Molecular Weight:502.464
Hs Code.:

Synonyms:Benzoic acid (2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of Benzoic acid (2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester

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Technology Process of Benzoic acid (2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester

There total 15 articles about Benzoic acid (2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 18055-46-4
bis(trimethylsilyl)-N⁶-benzoyladenine

: 133776-29-1
2-azido-5-O-benzoyl-3-fluoro-2,3-dideoxy-β-D-ribofuranoside

: 133776-11-1
2-azido-5-O-benzoyl-2,3-dideoxy-3-fluoro-α-D-ribofuranoside

: 133776-32-6
Benzoic acid (2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With tin(IV) chloride; In 1,2-dichloro-ethane; acetonitrile; for 5h; Heating;
DOI:10.1021/jm00111a040

Reference yield:

: C₃₁H₂₃N₅O₆

: C₂₄H₁₉FN₈O₄

: 133776-32-6
Benzoic acid (2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: C₃₁H₂₃N₅O₆; With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 50 ℃; for 5h; Inert atmosphere;

With Nonafluorobutanesulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 ℃; for 1.66667h; Overall yield = 6 g; Inert atmosphere;

Reference yield:

: C₂₄H₁₉N₅O₅

: C₂₄H₁₉FN₈O₄

: 133776-32-6
Benzoic acid (2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: C₂₄H₁₉N₅O₅; With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; Heating;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 ℃; for 1.5h; Overall yield = 9.2 g; Inert atmosphere;