(3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Base Information

• Chemical Name: (3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• CAS No.: 207228-30-6
• Molecular Formula: C₂₄H₂₈N₂O₅
• Molecular Weight: 424.497
• Mol file: 207228-30-6.mol

Synonyms:(3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Chemical Property of (3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

There total 1 articles about (3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester (1036717-90-4) → (3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (207228-30-6)

Guidance literature:

(3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester; With sodium hydroxide; water; In methanol; at 0 ℃; for 3h; Inert atmosphere;

With potassium hydrogensulfate; water; In methanol; pH=2 - 7; Inert atmosphere;

DOI:10.1016/j.bmc.2008.09.019

Reference yield: 94.0%

(3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (207228-30-6) + L-Phenylalanine benzyl ester (962-39-0) → N-((3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-phenylalanine benzyl ester (1219835-38-7)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 14h; under 750.075 Torr; pH=9; Inert atmosphere;

DOI:10.1016/j.bmc.2010.01.009

Reference yield: 92.0%

(3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (207228-30-6) → (3S)-N-(L-phenylalanyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (207228-35-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2008.09.019

upstream raw materials:

(3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester

Downstream raw materials:

(3S)-N-(L-phenylalanyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

N-((3S)-N-(Boc-L-phenylalaninyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-phenylalanine benzyl ester