(2R,6S)-6-iodo-2-(2-iodo-4-isopropyl-3,5-dimethoxyphenyl)-2-methylcyclohexanone

Base Information

Chemical Name:(2R,6S)-6-iodo-2-(2-iodo-4-isopropyl-3,5-dimethoxyphenyl)-2-methylcyclohexanone
CAS No.:1265899-62-4
Molecular Formula:C₁₈H₂₄I₂O₃
Molecular Weight:542.196
Hs Code.:

Synonyms:(2R,6S)-6-iodo-2-(2-iodo-4-isopropyl-3,5-dimethoxyphenyl)-2-methylcyclohexanone

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Chemical Property of (2R,6S)-6-iodo-2-(2-iodo-4-isopropyl-3,5-dimethoxyphenyl)-2-methylcyclohexanone

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Technology Process of (2R,6S)-6-iodo-2-(2-iodo-4-isopropyl-3,5-dimethoxyphenyl)-2-methylcyclohexanone

There total 11 articles about (2R,6S)-6-iodo-2-(2-iodo-4-isopropyl-3,5-dimethoxyphenyl)-2-methylcyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1265899-61-3
(R)-2-(4-isopropyl-3,5-dimethoxyphenyl)-2-methylcyclohexanone

: 1265899-62-4
(2R,6S)-6-iodo-2-(2-iodo-4-isopropyl-3,5-dimethoxyphenyl)-2-methylcyclohexanone

Guidance literature:: With iodine; silver sulfate; In methanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ja110215b

Reference yield:

: 1265899-60-2
(R,E)-2-(4-isopropyl-3,5-dimethoxyphenyl)-2-methyl-6-((methyl(phenyl)amino)methylene)-cyclohexanone

: 1265899-62-4
(2R,6S)-6-iodo-2-(2-iodo-4-isopropyl-3,5-dimethoxyphenyl)-2-methylcyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2: sodium hydroxide / water / 6 h / 90 °C / Inert atmosphere

3: iodine; silver sulfate / methanol / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; iodine; silver sulfate; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1021/ja110215b

Reference yield:

: (E)-2-methyl-6-((methyl(phenyl)amino)methylene)cyclohexanone

: 1265899-62-4
(2R,6S)-6-iodo-2-(2-iodo-4-isopropyl-3,5-dimethoxyphenyl)-2-methylcyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1: (R)-(-)-5,5’-bis(diphenyl;phosphine)-2,2,2’,2’-tetrafluoro-4,4’-bi-1,3-benzodioxole; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate / toluene / 72 h / 80 °C / Inert atmosphere; Sealed vessel

2: hydrogenchloride; water / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3: sodium hydroxide / water / 6 h / 90 °C / Inert atmosphere

4: iodine; silver sulfate / methanol / 3 h / 20 °C / Inert atmosphere

With (R)-(-)-5,5’-bis(diphenyl;phosphine)-2,2,2’,2’-tetrafluoro-4,4’-bi-1,3-benzodioxole; hydrogenchloride; water; iodine; silver sulfate; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In tetrahydrofuran; methanol; water; toluene;
DOI:10.1021/ja110215b