2-bromophenethyl N,N,N',N'-tetrakis(2-chloroethyl)chlorophosphoramidate

Base Information

Chemical Name:2-bromophenethyl N,N,N',N'-tetrakis(2-chloroethyl)chlorophosphoramidate
CAS No.:175443-42-2
Molecular Formula:C₁₆H₂₄BrCl₄N₂O₂P
Molecular Weight:529.069
Hs Code.:

Synonyms:2-bromophenethyl N,N,N',N'-tetrakis(2-chloroethyl)chlorophosphoramidate

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Chemical Property of 2-bromophenethyl N,N,N',N'-tetrakis(2-chloroethyl)chlorophosphoramidate

Chemical Property:

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Technology Process of 2-bromophenethyl N,N,N',N'-tetrakis(2-chloroethyl)chlorophosphoramidate

There total 5 articles about 2-bromophenethyl N,N,N',N'-tetrakis(2-chloroethyl)chlorophosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.4%

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 175443-41-1
2-bromophenethyl N,N-bis(2-chloroethyl)chlorophosphoramidite

: 175443-42-2
2-bromophenethyl N,N,N',N'-tetrakis(2-chloroethyl)chlorophosphoramidate

Guidance literature:: With triethylamine; In ethyl acetate; for 72h; Heating;
DOI:10.1021/jm950005k

Reference yield:

: 96-09-3
styrene oxide

: 175443-42-2
2-bromophenethyl N,N,N',N'-tetrakis(2-chloroethyl)chlorophosphoramidate

Guidance literature:: Multi-step reaction with 3 steps

1: 22 percent / bromotrimethylsilane / acetonitrile / 22 h / Ambient temperature

2: 1.) POCl₃, Et₃N, 2.) Et₃N / 1.) CH₂Cl₂, RT, 17 h, 2.) CH₂Cl₂, RT, 3 d

3: 56.4 percent / Et₃N / ethyl acetate / 72 h / Heating

With trimethylsilyl bromide; triethylamine; trichlorophosphate; In ethyl acetate; acetonitrile;
DOI:10.1021/jm950005k

Reference yield:

: 4870-65-9,31302-84-8
2-bromophenylacetic acid

: 175443-42-2
2-bromophenethyl N,N,N',N'-tetrakis(2-chloroethyl)chlorophosphoramidate

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / BH₃*THF / tetrahydrofuran / 3 h / 5 - 10 °C

2: 1.) POCl₃, Et₃N, 2.) Et₃N / 1.) CH₂Cl₂, RT, 17 h, 2.) CH₂Cl₂, RT, 3 d

3: 56.4 percent / Et₃N / ethyl acetate / 72 h / Heating

With borane-THF; triethylamine; trichlorophosphate; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm950005k