((3aR,4R,6R,7S,7aR)-6-Formyl-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-methyl-carbamic acid benzyl ester

Base Information

Chemical Name:((3aR,4R,6R,7S,7aR)-6-Formyl-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-methyl-carbamic acid benzyl ester
CAS No.:357271-87-5
Molecular Formula:C₁₉H₂₅NO₇
Molecular Weight:379.41
Hs Code.:

Synonyms:((3aR,4R,6R,7S,7aR)-6-Formyl-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-methyl-carbamic acid benzyl ester

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Chemical Property of ((3aR,4R,6R,7S,7aR)-6-Formyl-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-methyl-carbamic acid benzyl ester

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Technology Process of ((3aR,4R,6R,7S,7aR)-6-Formyl-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-methyl-carbamic acid benzyl ester

There total 6 articles about ((3aR,4R,6R,7S,7aR)-6-Formyl-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-methyl-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

: 357271-86-4
((3aR,4R,6R,7R,7aR)-6-Hydroxymethyl-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-methyl-carbamic acid benzyl ester

: 357271-87-5
((3aR,4R,6R,7S,7aR)-6-Formyl-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-methyl-carbamic acid benzyl ester

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -61 - 0 ℃;
DOI:10.1021/ol010119s

Reference yield:

: (3aR,4R,6S,7S,7aR)-6-Hydroxymethyl-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ol

: 357271-87-5
((3aR,4R,6R,7S,7aR)-6-Formyl-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-methyl-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98.7 percent / Et₃N / 168 h / 23 °C

2: 85 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

3: 0.266 g / KH; 18-crown-6 / tetrahydrofuran / 4 h / -30 °C

4: NaOH / H₂O / 4 h / Heating

5: 542 mg / K₂CO₃ / dioxane; H₂O / 10 h / 23 °C

6: 93.1 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -61 - 0 °C

With pyridine; sodium hydroxide; oxalyl dichloride; 18-crown-6 ether; potassium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ol010119s

Reference yield:

: 357271-85-3
((3aR,4R,6R,7R,7aR)-4-Methoxy-2,2-dimethyl-7-methylamino-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-methanol

: 357271-87-5
((3aR,4R,6R,7S,7aR)-6-Formyl-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-methyl-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 542 mg / K₂CO₃ / dioxane; H₂O / 10 h / 23 °C

2: 93.1 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -61 - 0 °C

With oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ol010119s