2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2R,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-3-methyl-butyl)-2-hydroxy-5-methyl-hexyl ester

Base Information

Chemical Name:2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2R,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-3-methyl-butyl)-2-hydroxy-5-methyl-hexyl ester
CAS No.:247575-92-4
Molecular Formula:C₄₈H₆₅N₃O₄
Molecular Weight:748.062
Hs Code.:

2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2R,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-3-methyl-butyl)-2-hydroxy-5-methyl-hexyl ester

Synonyms:2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2R,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-3-methyl-butyl)-2-hydroxy-5-methyl-hexyl ester

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Chemical Property of 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2R,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-3-methyl-butyl)-2-hydroxy-5-methyl-hexyl ester

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Technology Process of 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2R,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-3-methyl-butyl)-2-hydroxy-5-methyl-hexyl ester

There total 3 articles about 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2R,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-3-methyl-butyl)-2-hydroxy-5-methyl-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 247575-89-9
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-3-methyl-butyl)-5-methyl-2-oxo-hexyl ester

: 247575-92-4
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2R,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-3-methyl-butyl)-2-hydroxy-5-methyl-hexyl ester

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 24h; Heating;
DOI:10.1055/s-1999-3576

Reference yield:

: 143746-14-9
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-4-methyl-pentyl ester

: 247575-92-4
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2R,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-3-methyl-butyl)-2-hydroxy-5-methyl-hexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: s-BuLi; TMEDA / diethyl ether; cyclohexane; hexane / 6 h / -78 °C

1.2: 26 percent / diethyl ether; cyclohexane; hexane / 12 h / -78 - 20 °C

2.1: 93 percent / NaBH₄ / ethanol / 24 h / Heating

With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; ethanol; hexane; cyclohexane; 1.1: Metallation / 1.2: Acylation / 2.1: Reduction;
DOI:10.1055/s-1999-3576

Reference yield:

: 111060-50-5
(S)-benzyl 2-(dibenzylamino)-4-methylpentanoate

: 247575-92-4
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2R,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-3-methyl-butyl)-2-hydroxy-5-methyl-hexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: s-BuLi; TMEDA / diethyl ether; cyclohexane; hexane / 6 h / -78 °C

1.2: 26 percent / diethyl ether; cyclohexane; hexane / 12 h / -78 - 20 °C

2.1: 93 percent / NaBH₄ / ethanol / 24 h / Heating

With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; ethanol; hexane; cyclohexane; 1.1: Metallation / 1.2: Acylation / 2.1: Reduction;
DOI:10.1055/s-1999-3576