1-(4-(tert-butyl)benzyl)-4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazole

Base Information

• Chemical Name: 1-(4-(tert-butyl)benzyl)-4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazole
• CAS No.: 1352060-39-9
• Molecular Formula: C₂₃H₂₉N₃
• Molecular Weight: 347.503
• Mol file: 1352060-39-9.mol

Synonyms:1-(4-(tert-butyl)benzyl)-4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazole

Chemical Property of 1-(4-(tert-butyl)benzyl)-4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-(tert-butyl)benzyl)-4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazole

There total 3 articles about 1-(4-(tert-butyl)benzyl)-4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-tert-Butylphenylacetylene (772-38-3) + 1-(bromomethyl)-4-(1,1-dimethylethyl)benzene (18880-00-7) → 1-(4-(tert-butyl)benzyl)-4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazole (1352060-39-9)

Guidance literature:

With sodium azide; (1,3-bis(2,6-diisopropyl-4-((triethylammonium)methyl)phenyl)imidazolidin-2-yl)copper(I) chloride; In water; at 20 ℃; for 3h;

DOI:10.1039/c1gc15871f

Reference yield: 71.0%

4-tert-Butylphenylacetylene (772-38-3) + 4-tert-butylbenzyl azide → 1-(4-(tert-butyl)benzyl)-4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazole (1352060-39-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 70 ℃; for 8h;

DOI:10.1021/acs.jmedchem.0c01521

Reference yield:

1-(bromomethyl)-4-(1,1-dimethylethyl)benzene (18880-00-7) → 1-(4-(tert-butyl)benzyl)-4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazole (1352060-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; copper(l) iodide / dimethyl sulfoxide; water / 0.5 h / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 8 h / 70 °C

With copper(l) iodide; sodium azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; dimethyl sulfoxide;

DOI:10.1021/acs.jmedchem.0c01521

upstream raw materials:

4-tert-Butylphenylacetylene

1-(bromomethyl)-4-(1,1-dimethylethyl)benzene