1-benzyl-3-hydroxy-3-hydroxymethyl azetidin-2-one

Base Information

• Chemical Name: 1-benzyl-3-hydroxy-3-hydroxymethyl azetidin-2-one
• CAS No.: 75986-05-9
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol file: 75986-05-9.mol

Synonyms:1-benzyl-3-hydroxy-3-hydroxymethyl azetidin-2-one

Chemical Property of 1-benzyl-3-hydroxy-3-hydroxymethyl azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1-benzyl-3-hydroxy-3-hydroxymethyl azetidin-2-one

There total 2 articles about 1-benzyl-3-hydroxy-3-hydroxymethyl azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.7%

N-benzyl-3-methyleneazetidin-2-one (72551-11-2) → 1-benzyl-3-hydroxy-3-hydroxymethyl azetidin-2-one (75986-05-9)

Guidance literature:

With 4-methylmorpholine N-oxide; osmium(VIII) oxide; In water; acetone; tert-butyl alcohol; for 168h;

DOI:10.1016/S0040-4020(01)96430-0

Reference yield:

N-(2-bromoallyl)benzylamine (72551-10-1) → 1-benzyl-3-hydroxy-3-hydroxymethyl azetidin-2-one (75986-05-9)

Guidance literature:

Multi-step reaction with 2 steps

2: 93.7 percent / OsO₄, N-methylmorpholine N-oxide

With osmium(VIII) oxide; 4-methylmorpholine N-oxide;

DOI:10.1039/c39800000770

Reference yield: 96.7%

1-benzyl-3-hydroxy-3-hydroxymethyl azetidin-2-one (75986-05-9) → N-benzylazetidine-2,3-dione (75986-07-1)

Guidance literature:

With sodium periodate; In tetrahydrofuran; water; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(01)96430-0

upstream raw materials:

N-benzyl-3-methyleneazetidin-2-one

N-(2-bromoallyl)benzylamine

Downstream raw materials:

N-benzylazetidine-2,3-dione

1-benzyl azetidine-2,3-dion-3-oxime

3-acetylamino-1-benzyl azetidin-2-one