2-Bromo-4-aminomethylaniline

Base Information

• Chemical Name: 2-Bromo-4-aminomethylaniline
• CAS No.: 42580-43-8
• Molecular Formula: C₇H₉BrN₂
• Molecular Weight: 201.066
• Mol file: 42580-43-8.mol

Synonyms:2-Bromo-4-aminomethylaniline

Chemical Property of 2-Bromo-4-aminomethylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4-aminomethylaniline

There total 3 articles about 2-Bromo-4-aminomethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-4-cyanoaniline (50397-74-5) → 2-Bromo-4-aminomethylaniline (42580-43-8)

Guidance literature:

2-bromo-4-cyanoaniline; With borane-THF; In tetrahydrofuran; for 2h; Heating;

With hydrogenchloride; In tetrahydrofuran; for 14h; Heating;

DOI:10.1021/jm0502790

Reference yield:

4-Aminobenzonitrile (873-74-5) → 2-Bromo-4-aminomethylaniline (42580-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 69 percent / NBS / dimethylformamide / 0.5 h

2.1: BH₃*THF / tetrahydrofuran / 2 h / Heating

2.2: aq. HCl / tetrahydrofuran / 14 h / Heating

With N-Bromosuccinimide; borane-THF; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm0502790

Reference yield:

→ 2-Bromo-4-aminomethylaniline (42580-43-8)

Guidance literature:

3-Brom-4-methylacetanilid, N-Bromsuccinimid;

upstream raw materials:

2-bromo-4-cyanoaniline

4-Aminobenzonitrile

Downstream raw materials:

tert-butyl N-(4-amino-3-bromobenzyl)carbamate

tert-butyl N-3-bromo-4-[(methylsulfonyl)amino]benzylcarbamate