((R)-1-Phenyl-ethyl)-carbamic acid (1S,2R)-2-benzyloxy-1,3-dimethyl-but-3-enyl ester

Base Information

• Chemical Name: ((R)-1-Phenyl-ethyl)-carbamic acid (1S,2R)-2-benzyloxy-1,3-dimethyl-but-3-enyl ester
• CAS No.: 161974-23-8
• Molecular Formula: C₂₂H₂₇NO₃
• Molecular Weight: 353.461
• Mol file: 161974-23-8.mol

Synonyms:((R)-1-Phenyl-ethyl)-carbamic acid (1S,2R)-2-benzyloxy-1,3-dimethyl-but-3-enyl ester

Chemical Property of ((R)-1-Phenyl-ethyl)-carbamic acid (1S,2R)-2-benzyloxy-1,3-dimethyl-but-3-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((R)-1-Phenyl-ethyl)-carbamic acid (1S,2R)-2-benzyloxy-1,3-dimethyl-but-3-enyl ester

There total 3 articles about ((R)-1-Phenyl-ethyl)-carbamic acid (1S,2R)-2-benzyloxy-1,3-dimethyl-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Benzyloxy-4-methyl-pent-4-en-2-one (161974-21-6) → ((R)-1-Phenyl-ethyl)-carbamic acid (1S,2R)-2-benzyloxy-1,3-dimethyl-but-3-enyl ester (161974-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / LiAlH₄ / diethyl ether

2: neat (no solvent)

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1016/S0040-4039(00)73311-9

Reference yield:

1,1-Bis-benzyloxy-2,3-dimethyl-but-3-en-2-ol → ((R)-1-Phenyl-ethyl)-carbamic acid (1S,2R)-2-benzyloxy-1,3-dimethyl-but-3-enyl ester (161974-23-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / AlCl₃ / diethyl ether / 1 h / -78 deg C to room t.

2: 78 percent / LiAlH₄ / diethyl ether

3: neat (no solvent)

With lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether;

DOI:10.1016/S0040-4039(00)73311-9

Reference yield:

(1R)-1-phenylethyl isocyanate (33375-06-3) + (2S,3R)-3-Benzyloxy-4-methyl-pent-4-en-2-ol → ((R)-1-Phenyl-ethyl)-carbamic acid (1S,2R)-2-benzyloxy-1,3-dimethyl-but-3-enyl ester (161974-23-8)

Guidance literature:

In neat (no solvent); Yield given;

DOI:10.1016/S0040-4039(00)73311-9

upstream raw materials:

(1R)-1-phenylethyl isocyanate

3-Benzyloxy-4-methyl-pent-4-en-2-one

Downstream raw materials:

(3R,4S,5S)-4-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-3-methyl-hexanal

[(1S,2S)-2-Benzyloxy-1-methyl-2-((R)-2-methyl-oxiranyl)-ethoxy]-tert-butyl-dimethyl-silane

(2R,3S,4S)-3-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-[1,3]dithian-2-yl-2-methyl-pentan-2-ol

(1S,2S)-1-Benzyloxy-1-((R)-2-methyl-oxiranyl)-propan-2-ol