Methanesulfonic acid 1-(4-methyl-benzoyl)-azetidin-3-yl ester

Base Information

• Chemical Name: Methanesulfonic acid 1-(4-methyl-benzoyl)-azetidin-3-yl ester
• CAS No.: 136911-53-0
• Molecular Formula: C₁₂H₁₅NO₄S
• Molecular Weight: 269.321
• Mol file: 136911-53-0.mol

Synonyms:Methanesulfonic acid 1-(4-methyl-benzoyl)-azetidin-3-yl ester

Chemical Property of Methanesulfonic acid 1-(4-methyl-benzoyl)-azetidin-3-yl ester

Chemical Property:

Purity/Quality:

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Technology Process of Methanesulfonic acid 1-(4-methyl-benzoyl)-azetidin-3-yl ester

There total 1 articles about Methanesulfonic acid 1-(4-methyl-benzoyl)-azetidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

azetidin-3-yl methanesulfonate hydrochloride (36476-89-8) + 4-methyl-benzoyl chloride (874-60-2) → Methanesulfonic acid 1-(4-methyl-benzoyl)-azetidin-3-yl ester (136911-53-0)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 25 ℃; for 4h;

DOI:10.1021/jo00024a001

Reference yield: 93.0%

Methanesulfonic acid 1-(4-methyl-benzoyl)-azetidin-3-yl ester (136911-53-0) → (2H-Azet-1-yl)-p-tolyl-methanone (136911-57-4)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 40 - 50 ℃;

DOI:10.1021/jo00024a001

upstream raw materials:

azetidin-3-yl methanesulfonate hydrochloride

4-methyl-benzoyl chloride

Downstream raw materials:

(2H-Azet-1-yl)-p-tolyl-methanone