(+/-)-1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-piperidone

Base Information

Chemical Name:(+/-)-1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-piperidone
CAS No.:99707-38-7
Molecular Formula:C₁₉H₂₆N₂O₅
Molecular Weight:362.426
Hs Code.:

Synonyms:(+/-)-1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-piperidone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-piperidone

Chemical Property:

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Technology Process of (+/-)-1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-piperidone

There total 5 articles about (+/-)-1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 81867-37-0
benzyl iodoacetate

: 99780-98-0
(+/-)-3-<(tert-butoxycarbonyl)amino>-2-piperidone

: 99707-38-7,1256385-95-1
(+/-)-1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-piperidone

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; for 3.5h; Ambient temperature;
DOI:10.1021/jm00152a014

Reference yield: 45.0%

: 99780-98-0
(+/-)-3-<(tert-butoxycarbonyl)amino>-2-piperidone

: 5437-45-6
Benzyl bromoacetate

: 99707-38-7,1256385-95-1
(+/-)-1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-piperidone

Guidance literature:: (+/-)-3-<(tert-butoxycarbonyl)amino>-2-piperidone; With lithium hexamethyldisilazane; In tetrahydrofuran; for 0.5h; Inert atmosphere;

Benzyl bromoacetate; In tetrahydrofuran; for 0.5h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 1892-22-4,4077-38-7,34294-79-6,88763-76-2
3-aminopiperidin-2-one

: 99707-38-7,1256385-95-1
(+/-)-1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-piperidone

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / triethylamine / CH₂Cl₂ / 3 h / Ambient temperature

2: 56 percent / NaH / dimethylformamide; tetrahydrofuran / 3.5 h / Ambient temperature

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00152a014