ethyl N-[4-(9-methyl-5-(methylsulfanyl)-2-oxo-8-phenyl-3H-imidazo[1,2-c]pyrrolo[3,2-e]pyrimidin-7-yl)-butanoyl]glycinate

Base Information

Chemical Name:ethyl N-[4-(9-methyl-5-(methylsulfanyl)-2-oxo-8-phenyl-3H-imidazo[1,2-c]pyrrolo[3,2-e]pyrimidin-7-yl)-butanoyl]glycinate
CAS No.:1400787-98-5
Molecular Formula:C₂₄H₂₇N₅O₄S
Molecular Weight:481.575
Hs Code.:

Synonyms:ethyl N-[4-(9-methyl-5-(methylsulfanyl)-2-oxo-8-phenyl-3H-imidazo[1,2-c]pyrrolo[3,2-e]pyrimidin-7-yl)-butanoyl]glycinate

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Chemical Property of ethyl N-[4-(9-methyl-5-(methylsulfanyl)-2-oxo-8-phenyl-3H-imidazo[1,2-c]pyrrolo[3,2-e]pyrimidin-7-yl)-butanoyl]glycinate

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Technology Process of ethyl N-[4-(9-methyl-5-(methylsulfanyl)-2-oxo-8-phenyl-3H-imidazo[1,2-c]pyrrolo[3,2-e]pyrimidin-7-yl)-butanoyl]glycinate

There total 2 articles about ethyl N-[4-(9-methyl-5-(methylsulfanyl)-2-oxo-8-phenyl-3H-imidazo[1,2-c]pyrrolo[3,2-e]pyrimidin-7-yl)-butanoyl]glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1400787-94-1
C₂₀H₂₀N₄O₃S

: 623-33-6
glycine ethyl ester hydrochloride

: 1400787-98-5
ethyl N-[4-(9-methyl-5-(methylsulfanyl)-2-oxo-8-phenyl-3H-imidazo[1,2-c]pyrrolo[3,2-e]pyrimidin-7-yl)-butanoyl]glycinate

Guidance literature:: C₂₀H₂₀N₄O₃S; With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 1h;

glycine ethyl ester hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2012.07.046

Reference yield:

: 61404-76-0
2-amino-3-cyano-4-methyl-5-phenylpyrrole

: 1400787-98-5
ethyl N-[4-(9-methyl-5-(methylsulfanyl)-2-oxo-8-phenyl-3H-imidazo[1,2-c]pyrrolo[3,2-e]pyrimidin-7-yl)-butanoyl]glycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

3.1: potassium hydroxide / ethanol; water / 12 h / 20 °C

3.2: pH 5

4.1: dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 °C

4.2: 24 h / 20 °C

With potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; potassium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.07.046