Technology Process of (1S,8aR)-1-(benzyloxy)-8,8-difluoro-1,2,3,5,8,8a-hexahydroindolizine
There total 6 articles about (1S,8aR)-1-(benzyloxy)-8,8-difluoro-1,2,3,5,8,8a-hexahydroindolizine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
toluene;
at 80 ℃;
for 10h;
DOI:10.1016/j.cclet.2014.04.018
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 0 - 20 °C
2: 10 h / 145 °C / Sealed tube
3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 10 h / 80 °C
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; triethylamine;
In
dichloromethane; toluene;
DOI:10.1016/j.cclet.2014.04.018
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: magnesium bromide diethyl etherate / dichloromethane / 1 h / 0 °C
1.2: 2 h / -90 °C
1.3: -90 - 20 °C
2.1: indium / N,N-dimethyl-formamide / 24 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C
4.1: triethylamine / dichloromethane / 0 - 20 °C
5.1: 10 h / 145 °C / Sealed tube
6.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 10 h / 80 °C
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; indium; lithium aluminium tetrahydride; magnesium bromide diethyl etherate; triethylamine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.cclet.2014.04.018
