(2S,4R)-4-(2-chlorobenzenesulfonyl)-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine hydrochloric acid

Base Information

Chemical Name:(2S,4R)-4-(2-chlorobenzenesulfonyl)-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine hydrochloric acid
CAS No.:1252632-39-5
Molecular Formula:C₁₅H₁₆ClN₃O₃S*ClH
Molecular Weight:390.29
Hs Code.:

Synonyms:(2S,4R)-4-(2-chlorobenzenesulfonyl)-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine hydrochloric acid

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Chemical Property of (2S,4R)-4-(2-chlorobenzenesulfonyl)-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine hydrochloric acid

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Technology Process of (2S,4R)-4-(2-chlorobenzenesulfonyl)-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine hydrochloric acid

There total 7 articles about (2S,4R)-4-(2-chlorobenzenesulfonyl)-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine hydrochloric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1252632-24-8
tert-butyl (2S,4R)-4-[(2-chlorophenyl)sulfonyl]-2-{[(1-cyanocyclopropyl)amino]carbonyl}pyrrolidine-1-carboxylate

: 1252632-39-5
(2S,4R)-4-(2-chlorobenzenesulfonyl)-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine hydrochloric acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 22 ℃;
DOI:10.1021/jm401528k

Reference yield:

: 121147-93-1
(2S,4S)-2-methyl N-Boc-4-((methylsulfonyl)oxy)pyrrolidine-2-carboxylate

: 1252632-39-5
(2S,4R)-4-(2-chlorobenzenesulfonyl)-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine hydrochloric acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 22 °C

1.2: 50 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 22 °C

4.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.5 h / -16 °C

4.2: 22 °C

5.1: hydrogenchloride / 1,4-dioxane / 22 °C

With 4-methyl-morpholine; hydrogenchloride; water; sodium hydride; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; mineral oil;
DOI:10.1021/jm401528k

Reference yield:

: 74844-91-0,114676-69-6,135042-17-0,227935-38-8,102195-79-9
(2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester

: 1252632-39-5
(2S,4R)-4-(2-chlorobenzenesulfonyl)-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine hydrochloric acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 5 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 22 °C

2.2: 50 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 22 °C

5.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.5 h / -16 °C

5.2: 22 °C

6.1: hydrogenchloride / 1,4-dioxane / 22 °C

With 4-methyl-morpholine; hydrogenchloride; water; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; mineral oil;
DOI:10.1021/jm401528k