5-Chloro-1-{3-[4-(3-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril

Base Information

Chemical Name:5-Chloro-1-{3-[4-(3-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril
CAS No.:182954-78-5
Molecular Formula:C₂₂H₂₅ClN₄O₃
Molecular Weight:428.918
Hs Code.:

Synonyms:5-Chloro-1-{3-[4-(3-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril

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Chemical Property of 5-Chloro-1-{3-[4-(3-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril

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Technology Process of 5-Chloro-1-{3-[4-(3-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril

There total 3 articles about 5-Chloro-1-{3-[4-(3-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54054-85-2
1-(3-nitrophenyl)piperazine

: 5-chloro-1-(3-iodo-propyl)-3,4-dihydro-1H-quinolin-2-one

: 182954-78-5
5-Chloro-1-{3-[4-(3-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril

Guidance literature:: With sodium carbonate; In acetonitrile; at 80 ℃;
DOI:10.1021/jm980333v

Reference yield:

: 72995-15-4
5-chloro-3,4-dihydro-2(1H)-quinolinone

: 182954-78-5
5-Chloro-1-{3-[4-(3-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 20 °C

1.2: 54 percent / dimethylformamide / 20 °C

2.1: NaI / acetonitrile / Heating

3.1: Na₂CO₃ / acetonitrile / 80 °C

With sodium hydride; sodium carbonate; sodium iodide; In N,N-dimethyl-formamide; acetonitrile; 1.1: Metallation / 1.2: Alkylation / 2.1: Substitution / 3.1: amination;
DOI:10.1021/jm980333v

Reference yield:

: 260369-75-3
1-(3-bromopropyl)-5-chloro-3,4-dihydro-2(1H)-quinolinone

: 182954-78-5
5-Chloro-1-{3-[4-(3-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril

Guidance literature:: Multi-step reaction with 2 steps

1: NaI / acetonitrile / Heating

2: Na₂CO₃ / acetonitrile / 80 °C

With sodium carbonate; sodium iodide; In acetonitrile; 1: Substitution / 2: amination;
DOI:10.1021/jm980333v