6-acetoxy-2-(4-aminophenoxymethyl)-7-t-butyl-2-methylchroman

Base Information

• Chemical Name: 6-acetoxy-2-(4-aminophenoxymethyl)-7-t-butyl-2-methylchroman
• CAS No.: 107188-44-3
• Molecular Formula: C₂₃H₂₉NO₄
• Molecular Weight: 383.488
• Mol file: 107188-44-3.mol

Synonyms:6-acetoxy-2-(4-aminophenoxymethyl)-7-t-butyl-2-methylchroman

Chemical Property of 6-acetoxy-2-(4-aminophenoxymethyl)-7-t-butyl-2-methylchroman

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-acetoxy-2-(4-aminophenoxymethyl)-7-t-butyl-2-methylchroman

There total 6 articles about 6-acetoxy-2-(4-aminophenoxymethyl)-7-t-butyl-2-methylchroman which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-acetoxy-7-t-butyl-2-methyl-2-(4-nitrophenoxymethyl)-2H-chromene → 6-acetoxy-2-(4-aminophenoxymethyl)-7-t-butyl-2-methylchroman (107188-44-3)

Guidance literature:

With sodium hydrogencarbonate; acetic acid; In water; palladium; benzene;

Reference yield:

Acetic acid 7-tert-butyl-2-methyl-2-(4-nitro-phenoxymethyl)-chroman-6-yl ester → 6-acetoxy-2-(4-aminophenoxymethyl)-7-t-butyl-2-methylchroman (107188-44-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; benzene;

DOI:10.1021/jm00122a022

Reference yield:

7-tert-Butyl-2-hydroxymethyl-2-methyl-chroman-6-ol → 6-acetoxy-2-(4-aminophenoxymethyl)-7-t-butyl-2-methylchroman (107188-44-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, 2.) benzene

2: 1.) NaH / 1.) DMSO, benzene

3: AcOH, 10percent H₂SO₄

4: pyridine

5: H₂ / 10percent Pd-C / methanol; benzene

With pyridine; sulfuric acid; hydrogen; sodium hydride; acetic acid; palladium on activated charcoal; In methanol; benzene;

DOI:10.1021/jm00122a022

upstream raw materials:

(7-tert-Butyl-6-methoxymethoxy-2-methyl-chroman-2-yl)-methanol

Downstream raw materials:

5-[4-(7-t-Butyl-6-hydroxy-2-methylchroman-2-yl-methoxy)benzyl ]thiazolidine-2,4-dione