methyl 2-(7-(3-(4-trifluoromethylphenyl)benzyloxy)-3,4-dihydro-1H-isochromen-4-yl)acetate

Base Information

Chemical Name:methyl 2-(7-(3-(4-trifluoromethylphenyl)benzyloxy)-3,4-dihydro-1H-isochromen-4-yl)acetate
CAS No.:950505-72-3
Molecular Formula:C₂₆H₂₃F₃O₄
Molecular Weight:456.461
Hs Code.:

Synonyms:methyl 2-(7-(3-(4-trifluoromethylphenyl)benzyloxy)-3,4-dihydro-1H-isochromen-4-yl)acetate

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Chemical Property of methyl 2-(7-(3-(4-trifluoromethylphenyl)benzyloxy)-3,4-dihydro-1H-isochromen-4-yl)acetate

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Technology Process of methyl 2-(7-(3-(4-trifluoromethylphenyl)benzyloxy)-3,4-dihydro-1H-isochromen-4-yl)acetate

There total 7 articles about methyl 2-(7-(3-(4-trifluoromethylphenyl)benzyloxy)-3,4-dihydro-1H-isochromen-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 638214-11-6
3-(bromomethyl)-4'-(trifluoromethyl)-1,1'-biphenyl

: 1057338-90-5
methyl 2-(7-hydroxy-3,4-dihydro-1H-isochromen-4-yl)acetate

: 950505-72-3
methyl 2-(7-(3-(4-trifluoromethylphenyl)benzyloxy)-3,4-dihydro-1H-isochromen-4-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 950505-62-1
(5-(4-methoxybenzyloxy)-2-bromophenyl)methanol

: 950505-72-3
methyl 2-(7-(3-(4-trifluoromethylphenyl)benzyloxy)-3,4-dihydro-1H-isochromen-4-yl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydroxide; tetra-(n-butyl)ammonium iodide / dichloromethane; water / 17 h / 20 °C

2: N,N-dimethyl-formamide / 2 h / 85 °C

3: sodium hydroxide; water / ethanol / 19 h / 20 °C

4: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / 2 h / 85 °C

5: potassium permanganate / water; acetone / 20 °C

6: 0.08 h / 20 °C

7: hydrogen / palladium on activated charcoal / methanol / 0.17 h / 20 °C

8: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With sodium hydroxide; potassium permanganate; water; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; palladium diacetate; palladium on activated charcoal; tris-(o-tolyl)phosphine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 950505-60-9
5-(4-methoxybenzyloxy)-2-bromobenzaldehyde

: 950505-72-3
methyl 2-(7-(3-(4-trifluoromethylphenyl)benzyloxy)-3,4-dihydro-1H-isochromen-4-yl)acetate

Guidance literature:: Multi-step reaction with 9 steps

1: sodium tetrahydroborate / methanol / 4 h / Heating / reflux

2: sodium hydroxide; tetra-(n-butyl)ammonium iodide / dichloromethane; water / 17 h / 20 °C

3: N,N-dimethyl-formamide / 2 h / 85 °C

4: sodium hydroxide; water / ethanol / 19 h / 20 °C

5: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / 2 h / 85 °C

6: potassium permanganate / water; acetone / 20 °C

7: 0.08 h / 20 °C

8: hydrogen / palladium on activated charcoal / methanol / 0.17 h / 20 °C

9: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; potassium permanganate; water; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; palladium diacetate; palladium on activated charcoal; tris-(o-tolyl)phosphine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;