3-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]-1H-1,2,4-triazole

Base Information

Chemical Name:3-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]-1H-1,2,4-triazole
CAS No.:913653-14-2
Molecular Formula:C₁₉H₁₅ClN₄OS
Molecular Weight:382.873
Hs Code.:

Synonyms:3-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]-1H-1,2,4-triazole

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Chemical Property of 3-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]-1H-1,2,4-triazole

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Technology Process of 3-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]-1H-1,2,4-triazole

There total 9 articles about 3-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 913653-12-0
2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-[(1E)-(dimethylamino)methylidene]-1,3-thiazole-4-carboxamide

: 913653-14-2
3-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]-1H-1,2,4-triazole

Guidance literature:: With acetic acid; hydrazine; for 1h; Heating / reflux;

Reference yield:

: 1450-74-4
5-chloro-2-hydroxyacetophenone

: 913653-14-2
3-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / 2 h / Heating / reflux

2.1: iodine; silver nitrate / ethanol / 16 h / Heating / reflux

3.1: water / ethanol / 1.5 h / 90 °C

4.1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

5.1: Lawessons reagent / 1,2-dimethoxyethane / 2 h / 20 °C

6.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.08 h

6.2: 0.02 h

6.3: 1.5 h / 0 - 20 °C

7.1: sodium hydroxide; water / ethanol / 20 - 60 °C

8.1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

9.1: 2 h / 120 °C

10.1: acetic acid; hydrazine / 1 h / Heating / reflux

With Lawessons reagent; 4-methyl-morpholine; sodium hydroxide; N-hydroxybenzotriazole ammonium salt; water; iodine; potassium carbonate; potassium hydrogencarbonate; silver nitrate; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; hydrazine; In 1,2-dimethoxyethane; ethanol; dichloromethane;

Reference yield:

: 913651-21-5
2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazole-4-carboxylic acid

: 913653-14-2
3-[2-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-1,3-thiazol-4-yl]-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

2: 2 h / 120 °C

3: acetic acid; hydrazine / 1 h / Heating / reflux

With 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; hydrazine; In dichloromethane;