tert-butyl N-{3-[amino(hydroxyimino)methyl]-5-fluorobenzyl}-N-methylglycinate

Base Information

Chemical Name:tert-butyl N-{3-[amino(hydroxyimino)methyl]-5-fluorobenzyl}-N-methylglycinate
CAS No.:1246526-80-6
Molecular Formula:C₁₅H₂₂FN₃O₃
Molecular Weight:311.356
Hs Code.:

Synonyms:tert-butyl N-{3-[amino(hydroxyimino)methyl]-5-fluorobenzyl}-N-methylglycinate

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Chemical Property of tert-butyl N-{3-[amino(hydroxyimino)methyl]-5-fluorobenzyl}-N-methylglycinate

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Technology Process of tert-butyl N-{3-[amino(hydroxyimino)methyl]-5-fluorobenzyl}-N-methylglycinate

There total 3 articles about tert-butyl N-{3-[amino(hydroxyimino)methyl]-5-fluorobenzyl}-N-methylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246526-79-3
tert-butyl N-(3-cyano-5-fluorobenzyl)-N-methylglycinate

: 1246526-80-6
tert-butyl N-{3-[amino(hydroxyimino)methyl]-5-fluorobenzyl}-N-methylglycinate

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In ethanol; water;

Reference yield:

: 216976-30-6
3-fluoro-5-methylbenzonitrile

: 1246526-80-6
tert-butyl N-{3-[amino(hydroxyimino)methyl]-5-fluorobenzyl}-N-methylglycinate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / acetonitrile / 18 h / Reflux

2: potassium carbonate / acetonitrile / 18 h / 70 °C

3: hydroxylamine hydrochloride / water; ethanol / 15 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; potassium carbonate; In ethanol; water; acetonitrile;
DOI:10.1002/cmdc.201402557

Reference yield:

: 853368-35-1
3-(bromomethyl)-5-fluorobenzonitrile

: 1246526-80-6
tert-butyl N-{3-[amino(hydroxyimino)methyl]-5-fluorobenzyl}-N-methylglycinate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 18 h / 70 °C

2: hydroxylamine hydrochloride / water; ethanol / 15 h / 20 °C

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; water; acetonitrile;
DOI:10.1002/cmdc.201402557