N-((1,4,7-triazacyclononan-2-yl)methyl)-1-(4-(prop-2-yn-1-yloxy)phenyl)methanamine

Base Information

Chemical Name:N-((1,4,7-triazacyclononan-2-yl)methyl)-1-(4-(prop-2-yn-1-yloxy)phenyl)methanamine
CAS No.:1610596-57-0
Molecular Formula:C₁₇H₂₆N₄O
Molecular Weight:302.42
Hs Code.:

Synonyms:N-((1,4,7-triazacyclononan-2-yl)methyl)-1-(4-(prop-2-yn-1-yloxy)phenyl)methanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1,4,7-triazacyclononan-2-yl)methyl)-1-(4-(prop-2-yn-1-yloxy)phenyl)methanamine

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Technology Process of N-((1,4,7-triazacyclononan-2-yl)methyl)-1-(4-(prop-2-yn-1-yloxy)phenyl)methanamine

There total 7 articles about N-((1,4,7-triazacyclononan-2-yl)methyl)-1-(4-(prop-2-yn-1-yloxy)phenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1610596-47-8
(1,4,7-triazacyclononan-2-yl)methanamine

: 5651-86-5
4-(prop-2-ynyloxy)benzaldehyde

: 1610596-57-0
N-((1,4,7-triazacyclononan-2-yl)methyl)-1-(4-(prop-2-yn-1-yloxy)phenyl)methanamine

Guidance literature:: (1,4,7-triazacyclononan-2-yl)methanamine; 4-(prop-2-ynyloxy)benzaldehyde; In ethanol; at 20 ℃; for 48h;

With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 24h;

Reference yield:

: C₁₇H₂₄N₄O

: 1610596-57-0
N-((1,4,7-triazacyclononan-2-yl)methyl)-1-(4-(prop-2-yn-1-yloxy)phenyl)methanamine

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 12h;
DOI:10.1002/ejoc.201402708

Reference yield:

: C₂₈H₃₆N₄*3ClH

: 1610596-57-0
N-((1,4,7-triazacyclononan-2-yl)methyl)-1-(4-(prop-2-yn-1-yloxy)phenyl)methanamine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water / pH 14

2: palladium 10% on activated carbon; hydrogen; acetic acid / water; tetrahydrofuran / 240 h / 20 °C

3: ethanol / 48 h / 20 °C

4: sodium tetrahydroborate / ethanol / 12 h / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; acetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1002/ejoc.201402708