2-Amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

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Chemical Name:2-Amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine
CAS No.:136859-65-9
Molecular Formula:C₂₇H₃₁ClN₄O₃Si
Molecular Weight:523.107
Hs Code.:

Synonyms:2-Amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

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Chemical Property of 2-Amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

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Technology Process of 2-Amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

There total 1 articles about 2-Amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123439-70-3
2-amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

: 136859-65-9
2-Amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:: With sodium tetrahydroborate; CrO₃*pyridine*acetic anhydride; Yield given. Multistep reaction; 1) CH₂Cl₂, room temp.; 2) EtOH, 0 deg C, 2 h;
DOI:10.1002/hlca.19910740517

Reference yield: 94.0%

: 136859-65-9
2-Amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

: 14470-28-1
mono-4-methoxytrityl chloride

: 136859-67-1
4-Chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-2-<<(4-methoxytriphenyl)methyl>amino>-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In pyridine; for 3h; Ambient temperature;
DOI:10.1002/hlca.19910740517

Reference yield:

: 136859-65-9
2-Amino-4-chloro-7-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-threo-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

: 136883-87-9
2-Amino-4-chloro-7-<2,3-dideoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-3-fluoro-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / (i-Pr)2EtN / pyridine / 3 h / Ambient temperature

2: 29 percent / (Diethylamino)sulfur trifluoride / pyridine; CH₂Cl₂ / 0.25 h / Ambient temperature

3: 73 percent / 80percent aq.AcOH / 1 h / Ambient temperature

With diethylamino-sulfur trifluoride; acetic acid; N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;
DOI:10.1002/hlca.19910740517