(S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-(2,2,2-trifluoroacetamido)ethyl)piperidine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-(2,2,2-trifluoroacetamido)ethyl)piperidine-1-carboxylate
CAS No.:1231957-92-8
Molecular Formula:C₂₀H₂₅Cl₂F₃N₂O₃
Molecular Weight:469.331
Hs Code.:

Synonyms:(S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-(2,2,2-trifluoroacetamido)ethyl)piperidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-(2,2,2-trifluoroacetamido)ethyl)piperidine-1-carboxylate

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Technology Process of (S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-(2,2,2-trifluoroacetamido)ethyl)piperidine-1-carboxylate

There total 1 articles about (S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-(2,2,2-trifluoroacetamido)ethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1231957-90-6
(S)-tert-butyl 3-(2-aminoethyl)-3-(3,4-dichlorophenyl)piperidine-1-carboxylate

: 407-25-0
trifluoroacetic anhydride

: 1231957-92-8
(S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-(2,2,2-trifluoroacetamido)ethyl)piperidine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 18 - 25 ℃; for 2.16667h; Inert atmosphere;

Reference yield: 97.0%

: 1231957-92-8
(S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-(2,2,2-trifluoroacetamido)ethyl)piperidine-1-carboxylate

: 1231956-22-1
(S)-N-(2-(3-(3,4-dichlorophenyl)piperidin-3-yl)ethyl)-2,2,2-trifluoroacetamide

Guidance literature:: (S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-(2,2,2-trifluoroacetamido)ethyl)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 3h; Inert atmosphere;

With sodium hydroxide; In dichloromethane; at 18 - 25 ℃;

Reference yield: 88.0%

: 1231957-92-8
(S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-(2,2,2-trifluoroacetamido)ethyl)piperidine-1-carboxylate

: 1231957-51-9
(S)-N-(2-(3-(3,4-dichlorophenyl)piperidin-3-yl)ethyl)-2,2,2-trifluoroethanamine

Guidance literature:: (S)-tert-butyl 3-(3,4-dichlorophenyl)-3-(2-(2,2,2-trifluoroacetamido)ethyl)piperidine-1-carboxylate; With borane-THF; In tetrahydrofuran; at 80 ℃; for 72h; Inert atmosphere;

With hydrogenchloride; methanol; In tetrahydrofuran; diethyl ether; at 18 - 25 ℃;

With sodium hydroxide; In dichloromethane; at 18 - 25 ℃;