2-Cyano-5-methoxy-alpha-phenylbenzeneacetonitrile

Base Information

Chemical Name:2-Cyano-5-methoxy-alpha-phenylbenzeneacetonitrile
CAS No.:127667-07-6
Molecular Formula:C₁₆H₁₂N₂O
Molecular Weight:248.284
Hs Code.:
DSSTox Substance ID:DTXSID901253706
Nikkaji Number:J336.402J

Synonyms:DTXSID901253706;127667-07-6;2-Cyano-5-methoxy-alpha-phenylbenzeneacetonitrile

Suppliers and Price of 2-Cyano-5-methoxy-alpha-phenylbenzeneacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Cyano-5-methoxy-alpha-phenylbenzeneacetonitrile

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:248.094963011
Heavy Atom Count:19
Complexity:382

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)C#N)C(C#N)C2=CC=CC=C2

Technology Process of 2-Cyano-5-methoxy-alpha-phenylbenzeneacetonitrile

There total 2 articles about 2-Cyano-5-methoxy-alpha-phenylbenzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 140-29-4
phenylacetonitrile

: 127666-99-3
2-chloro-4-methoxylbenzonitrile

: 127667-07-6
2-(Cyano-phenyl-methyl)-4-methoxy-benzonitrile

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jo00303a011

Reference yield:

: 28163-00-0
4-nitro-2-chlorobenzonitrile

: 127667-07-6
2-(Cyano-phenyl-methyl)-4-methoxy-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / NaOH

2: 79 percent / potassium tert-butoxide / dimethylformamide / 1 h / 20 °C

With sodium hydroxide; potassium tert-butylate; In N,N-dimethyl-formamide;
DOI:10.1021/jo00303a011