3-[4-(benzyloxy)phenylsulfonyl]-8-tert-butoxycarbonyl-N-(tetrahydro-2H-pyran-2-yloxy)-8-azaspiro[4.5]decane-3-carboxamide

Base Information

Chemical Name:3-[4-(benzyloxy)phenylsulfonyl]-8-tert-butoxycarbonyl-N-(tetrahydro-2H-pyran-2-yloxy)-8-azaspiro[4.5]decane-3-carboxamide
CAS No.:1542206-00-7
Molecular Formula:C₃₃H₄₄N₂O₈S
Molecular Weight:628.787
Hs Code.:

Synonyms:3-[4-(benzyloxy)phenylsulfonyl]-8-tert-butoxycarbonyl-N-(tetrahydro-2H-pyran-2-yloxy)-8-azaspiro[4.5]decane-3-carboxamide

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Chemical Property of 3-[4-(benzyloxy)phenylsulfonyl]-8-tert-butoxycarbonyl-N-(tetrahydro-2H-pyran-2-yloxy)-8-azaspiro[4.5]decane-3-carboxamide

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Technology Process of 3-[4-(benzyloxy)phenylsulfonyl]-8-tert-butoxycarbonyl-N-(tetrahydro-2H-pyran-2-yloxy)-8-azaspiro[4.5]decane-3-carboxamide

There total 1 articles about 3-[4-(benzyloxy)phenylsulfonyl]-8-tert-butoxycarbonyl-N-(tetrahydro-2H-pyran-2-yloxy)-8-azaspiro[4.5]decane-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1542205-91-3
8-tert-butoxycarbonyl-3-(4-fluorophenylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-8-azaspiro[4.5]decane-3-carboxamide

: 100-51-6,185532-71-2
benzyl alcohol

: 1542206-00-7
3-[4-(benzyloxy)phenylsulfonyl]-8-tert-butoxycarbonyl-N-(tetrahydro-2H-pyran-2-yloxy)-8-azaspiro[4.5]decane-3-carboxamide

Guidance literature:: benzyl alcohol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

8-tert-butoxycarbonyl-3-(4-fluorophenylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-8-azaspiro[4.5]decane-3-carboxamide; In tetrahydrofuran; at 80 ℃; Inert atmosphere;
DOI:10.1021/jm501940y

Reference yield:

: 1542206-00-7
3-[4-(benzyloxy)phenylsulfonyl]-8-tert-butoxycarbonyl-N-(tetrahydro-2H-pyran-2-yloxy)-8-azaspiro[4.5]decane-3-carboxamide

: tert-butyl 3-[4-(2-ethoxycarbonylphenoxy)phenyl]sulfonyl-3-(tetrahydropyran-2-yloxycarbamoyl)-8-azaspiro[4.5]decane-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol / 1 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; caesium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm501940y

Reference yield:

: 1542206-00-7
3-[4-(benzyloxy)phenylsulfonyl]-8-tert-butoxycarbonyl-N-(tetrahydro-2H-pyran-2-yloxy)-8-azaspiro[4.5]decane-3-carboxamide

: 2-[4-[[8-tert-butoxycarbonyl-3-(tetrahydropyran-2-yloxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / methanol / 1 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; palladium on activated charcoal; hydrogen; caesium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm501940y