(R)-4-(1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl) 1-tert-butyl 4-phenylpiperidine-1,4-dicarboxylate

Base Information

Chemical Name:(R)-4-(1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl) 1-tert-butyl 4-phenylpiperidine-1,4-dicarboxylate
CAS No.:954124-26-6
Molecular Formula:C₂₆H₂₉BrF₃NO₄
Molecular Weight:556.42
Hs Code.:

Synonyms:(R)-4-(1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl) 1-tert-butyl 4-phenylpiperidine-1,4-dicarboxylate

Suppliers and Price of (R)-4-(1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl) 1-tert-butyl 4-phenylpiperidine-1,4-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (R)-4-(1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl) 1-tert-butyl 4-phenylpiperidine-1,4-dicarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-4-(1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl) 1-tert-butyl 4-phenylpiperidine-1,4-dicarboxylate

There total 1 articles about (R)-4-(1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl) 1-tert-butyl 4-phenylpiperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 954124-24-4
(R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethanol

: 167262-68-2
N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid

: 954124-26-6
(R)-4-(1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl) 1-tert-butyl 4-phenylpiperidine-1,4-dicarboxylate

Guidance literature:: N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid; With dicyclohexyl-carbodiimide; In dichloromethane; toluene; for 0.5h;

(R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethanol; With dmap; In dichloromethane; toluene; at 0 - 20 ℃; for 60h;

Reference yield: 24.0%

: 954124-26-6
(R)-4-(1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl) 1-tert-butyl 4-phenylpiperidine-1,4-dicarboxylate

: 108-24-7
acetic anhydride

: 954124-17-5
(R)-tert-butyl 4-((1-(3-bromo-5-(trifluoromethyl)phenyl)ethoxy)methyl)-4-phenylpiperidine-1-carboxylate

Guidance literature:: (R)-4-(1-(3-bromo-5-(trifluoromethyl)phenyl)ethyl) 1-tert-butyl 4-phenylpiperidine-1,4-dicarboxylate; With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 1h;

acetic anhydride; With pyridine; dmap; In dichloromethane; at -78 - -10 ℃;

With methanol; triethylsilane; boron trifluoride diethyl etherate; water; Rochelle's salt; more than 3 stages; Product distribution / selectivity;