(S)-2-((S)-1-bromoethyl)-1-((3-nitrophenyl)sulfonyl)-2-phenylpyrrolidine

Base Information

Chemical Name:(S)-2-((S)-1-bromoethyl)-1-((3-nitrophenyl)sulfonyl)-2-phenylpyrrolidine
CAS No.:1420479-57-7
Molecular Formula:C₁₈H₁₉BrN₂O₄S
Molecular Weight:439.33
Hs Code.:

Synonyms:(S)-2-((S)-1-bromoethyl)-1-((3-nitrophenyl)sulfonyl)-2-phenylpyrrolidine

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Chemical Property of (S)-2-((S)-1-bromoethyl)-1-((3-nitrophenyl)sulfonyl)-2-phenylpyrrolidine

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Technology Process of (S)-2-((S)-1-bromoethyl)-1-((3-nitrophenyl)sulfonyl)-2-phenylpyrrolidine

There total 5 articles about (S)-2-((S)-1-bromoethyl)-1-((3-nitrophenyl)sulfonyl)-2-phenylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1420479-36-2
(Z)-3-nitro-N-(4-phenylhex-4-en-1-yl)benzenesulfonamide

: 1420479-57-7
(S)-2-((S)-1-bromoethyl)-1-((3-nitrophenyl)sulfonyl)-2-phenylpyrrolidine

Guidance literature:: With N-bromophthalimide; (3aS,4S,6S,6aS)-2,2-dimethyl-4,6-bis((4-(tert-pentyl)phenoxy)methyl)tetrahydroselenopheno[3,4-d][1,3]dioxole; In dichloromethane; toluene; at -78 ℃; for 120h; Reagent/catalyst; Solvent; Time; enantioselective reaction; Inert atmosphere; Darkness;
DOI:10.1021/ja311202e

Reference yield:

: 1420479-36-2
(Z)-3-nitro-N-(4-phenylhex-4-en-1-yl)benzenesulfonamide

: (R)-2-((R)-1-bromoethyl)-1-((3-nitrophenyl)sulfonyl)-2-phenylpyrrolidine

: 1420479-57-7
(S)-2-((S)-1-bromoethyl)-1-((3-nitrophenyl)sulfonyl)-2-phenylpyrrolidine

Guidance literature:: With N-bromophthalimide; (3aS,4S,6S,6aS)-4,6-bis((4-isopropylphenoxy)methyl)-2,2-dimethyltetrahydroselenopheno[3,4-d][1,3]dioxole; In dichloromethane; toluene; at -78 ℃; for 120h; Overall yield = 85 %; enantioselective reaction; Inert atmosphere; Darkness;
DOI:10.1021/ja311202e

Reference yield:

: 1420480-10-9
(Z)-4-phenylhex-4-en-1-ol

: 1420479-57-7
(S)-2-((S)-1-bromoethyl)-1-((3-nitrophenyl)sulfonyl)-2-phenylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 2 h / 0 - 25 °C / Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h / 110 °C / Inert atmosphere

2.2: 1 h / 110 °C / Inert atmosphere

3.1: (3aS,4S,6S,6aS)-2,2-dimethyl-4,6-bis((4-(tert-pentyl)phenoxy)methyl)tetrahydroselenopheno[3,4-d][1,3]dioxole; N-bromophthalimide / dichloromethane; toluene / 120 h / -78 °C / Inert atmosphere; Darkness

With N-bromophthalimide; (3aS,4S,6S,6aS)-2,2-dimethyl-4,6-bis((4-(tert-pentyl)phenoxy)methyl)tetrahydroselenopheno[3,4-d][1,3]dioxole; triethylamine; potassium hydroxide; In dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/ja311202e