(2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-hydroxypyrrolidine-1,2-dicarboxylate
CAS No.:1256389-71-5
Molecular Formula:C₁₈H₂₂BrNO₆
Molecular Weight:428.28
Hs Code.:

Synonyms:(2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-hydroxypyrrolidine-1,2-dicarboxylate

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Chemical Property of (2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Chemical Property:

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Technology Process of (2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-hydroxypyrrolidine-1,2-dicarboxylate

There total 1 articles about (2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-hydroxypyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87691-27-8,946610-68-0
N-tert-butoxycarbonyl-L-cis-4-hydroxyproline

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 1256389-71-5
(2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Guidance literature:: With triethylamine; In acetonitrile; for 3h;

Reference yield:

: 1256389-71-5
(2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-hydroxypyrrolidine-1,2-dicarboxylate

: 1007882-07-6
(2S,4S)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-hydroxypyrrolidine-1-carboxylate

Guidance literature:: With ammonium acetate; In toluene; for 4h; Reflux;

Reference yield:

: 1256389-71-5
(2S,4S)-2-(2-(4-bromophenyl)-2-oxoethyl) 1-tert-butyl 4-hydroxypyrrolidine-1,2-dicarboxylate

: 1007882-15-6
(2S,4S)-tert-butyl 4-hydroxy-2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / toluene / 4 h / Reflux

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 18 h / 80 °C / Inert atmosphere

With ammonium acetate; potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; toluene;