2-butyl-1-<<2'-carboxy<1,1'-biphenyl>-4-yl>methyl>-4-chloro-1,6-dihydro-6-methyl-5-pyrimidinecarboxylic acid

Base Information

Chemical Name:2-butyl-1-<<2'-carboxy<1,1'-biphenyl>-4-yl>methyl>-4-chloro-1,6-dihydro-6-methyl-5-pyrimidinecarboxylic acid
CAS No.:145319-02-4
Molecular Formula:C₂₃H₂₅ClN₂O₂
Molecular Weight:396.917
Hs Code.:

Synonyms:2-butyl-1-<<2'-carboxy<1,1'-biphenyl>-4-yl>methyl>-4-chloro-1,6-dihydro-6-methyl-5-pyrimidinecarboxylic acid

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Chemical Property of 2-butyl-1-<<2'-carboxy<1,1'-biphenyl>-4-yl>methyl>-4-chloro-1,6-dihydro-6-methyl-5-pyrimidinecarboxylic acid

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Technology Process of 2-butyl-1-<<2'-carboxy<1,1'-biphenyl>-4-yl>methyl>-4-chloro-1,6-dihydro-6-methyl-5-pyrimidinecarboxylic acid

There total 5 articles about 2-butyl-1-<<2'-carboxy<1,1'-biphenyl>-4-yl>methyl>-4-chloro-1,6-dihydro-6-methyl-5-pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 145319-01-3
2-butyl-1-<<2'-carboxy<1,1'-biphenyl>-4-yl>methyl>-4-chloro-1,6-dihydro-6-methyl-5-pyrimidinecarboxylic acid

: 908093-98-1
diazodiphenylmethane

: 145319-02-4
2-butyl-1-<<2'-carboxy<1,1'-biphenyl>-4-yl>methyl>-4-chloro-1,6-dihydro-6-methyl-5-pyrimidinecarboxylic acid

Guidance literature:: In ethanol; for 0.916667h;
DOI:10.1021/jm00103a014

Reference yield:

: 142385-29-3
6-butyl-4-chloro-1,2-dihydro-2-methyl-3-pyrimidinecarboxylic acid, ethyl ester

: 145319-02-4
2-butyl-1-<<2'-carboxy<1,1'-biphenyl>-4-yl>methyl>-4-chloro-1,6-dihydro-6-methyl-5-pyrimidinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / potassium carbonate / dimethylformamide / Ambient temperature

2: 49.6 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / Ambient temperature

3: 44 percent / K₂HPO₄ / 408 h / 25 °C / porcine liver esterase

4: 81 percent / ethanol / 0.92 h

With dipotassium hydrogenphosphate; potassium carbonate; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00103a014

Reference yield:

: 142385-30-6
6-butyl-4-chloro-1-<2'-<(1,1-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-1,2-dihydro-2-methyl-3-pyrimidinecarboxylic acid, ethyl ester

: 145319-02-4
2-butyl-1-<<2'-carboxy<1,1'-biphenyl>-4-yl>methyl>-4-chloro-1,6-dihydro-6-methyl-5-pyrimidinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 49.6 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / Ambient temperature

2: 44 percent / K₂HPO₄ / 408 h / 25 °C / porcine liver esterase

3: 81 percent / ethanol / 0.92 h

With dipotassium hydrogenphosphate; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm00103a014