N-(N-tert-butoxycarbonyl-DL-phenylalanyl)-glycine methyl ester

Base Information

• Chemical Name: N-(N-tert-butoxycarbonyl-DL-phenylalanyl)-glycine methyl ester
• CAS No.: 106572-02-5
• Molecular Formula: C₁₇H₂₄N₂O₅
• Molecular Weight: 336.388
• Mol file: 106572-02-5.mol

Synonyms:N-(N-tert-butoxycarbonyl-DL-phenylalanyl)-glycine methyl ester

Chemical Property of N-(N-tert-butoxycarbonyl-DL-phenylalanyl)-glycine methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N-tert-butoxycarbonyl-DL-phenylalanyl)-glycine methyl ester

There total 4 articles about N-(N-tert-butoxycarbonyl-DL-phenylalanyl)-glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 2-tert-Butoxycarbonylamino-3-phenyl-propionic acid (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl ester (74293-09-7) → N-(tert-butoxycarbonyl)-L-phenylalanine (4530-18-1,13734-34-4,18942-49-9) + (2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-acetic acid methyl ester (7625-57-2,26582-93-4,106572-02-5)

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 38 ℃; for 96h;

DOI:10.1016/S0008-6215(00)81893-5

Reference yield: 27.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 2,3,4,6-tetra-O-benzyl-1-O-(N-tert-butoxycarbonyl-L-phenylalanyl)-β-D-glucopyranose (35909-82-1,74293-08-6) → N-(tert-butoxycarbonyl)-L-phenylalanine (4530-18-1,13734-34-4,18942-49-9) + (2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-acetic acid methyl ester (7625-57-2,26582-93-4,106572-02-5) + 2,3,4,6-tetra-O-benzyl-D-glucopyranose (4132-28-9,4291-69-4,6386-24-9,6564-72-3,59531-24-7,69257-52-9,78184-89-1,78609-16-2,78609-17-3,78609-18-4,96553-53-6,104111-61-7,131347-08-5)

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 38 ℃; for 96h;

DOI:10.1016/S0008-6215(00)81893-5

Reference yield:

N-tert-butoxycarbonyl-L-phenyl-alanine + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → N-(N-tert-butoxycarbonyl-DL-phenylalanyl)-glycine methyl ester (106572-02-5)

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

upstream raw materials:

2-(tert-butoxycarbonylamino)-3-phenylpropionic acid

tributyl-amine

methyl chloroformate

glycine ethyl ester hydrochloride

Downstream raw materials:

2-(2-(tert-butoxycarbonylamino)-3-phenylpropanamido)acetic acid

3-benzyl-piperazine-2,5-dione

phenylalanylglycine