2,6-dimethyl-4-(6-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Base Information

Chemical Name:2,6-dimethyl-4-(6-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester
CAS No.:108337-76-4
Molecular Formula:C₂₆H₂₈N₄O₄
Molecular Weight:460.533
Hs Code.:

Synonyms:2,6-dimethyl-4-(6-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

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Chemical Property of 2,6-dimethyl-4-(6-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2,6-dimethyl-4-(6-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

There total 10 articles about 2,6-dimethyl-4-(6-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108337-76-4
2,6-dimethyl-4-(6-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

: 103-67-3
benzyl-methyl-amine

Guidance literature:

Reference yield:

: 931-19-1
2-methylpyridine N-oxide

: 108337-76-4
2,6-dimethyl-4-(6-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 42.79 g / 24 h / Ambient temperature

2: ethanol; H₂O / 2.5 h / Ambient temperature

3: 92 percent / m-chloroperbenzoic acid / CHCl₃ / Ambient temperature

4: 50 percent / Heating

5: 75 percent / K₂CO₃ / methanol / 2.5 h

6: 81 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H₃PO₄ / 1.5 h / Ambient temperature

7: propan-2-ol / 40 °C

8: dimethylformamide / 100 - 110 °C

With phosphoric acid; potassium carbonate; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1248/cpb.38.2446

Reference yield:

: 1620-75-3
2-Cyano-6-methylpyridine

: 108337-76-4
2,6-dimethyl-4-(6-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / m-chloroperbenzoic acid / CHCl₃ / Ambient temperature

2: 50 percent / Heating

3: 75 percent / K₂CO₃ / methanol / 2.5 h

4: 81 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H₃PO₄ / 1.5 h / Ambient temperature

5: propan-2-ol / 40 °C

6: dimethylformamide / 100 - 110 °C

With phosphoric acid; potassium carbonate; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In methanol; chloroform; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1248/cpb.38.2446