5-[2-(4-fluoro-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl)ethyl]-2-benzofuran-1(3H)-one

Base Information

Chemical Name:5-[2-(4-fluoro-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl)ethyl]-2-benzofuran-1(3H)-one
CAS No.:1428477-32-0
Molecular Formula:C₂₄H₂₄FN₅O₃
Molecular Weight:449.485
Hs Code.:

Synonyms:5-[2-(4-fluoro-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl)ethyl]-2-benzofuran-1(3H)-one

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Chemical Property of 5-[2-(4-fluoro-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl)ethyl]-2-benzofuran-1(3H)-one

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Technology Process of 5-[2-(4-fluoro-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl)ethyl]-2-benzofuran-1(3H)-one

There total 8 articles about 5-[2-(4-fluoro-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl)ethyl]-2-benzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428479-65-5
5-[2-(4-hydroxy-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl)ethyl]-2-benzofuran-1(3H)-one

: 1428477-32-0
5-[2-(4-fluoro-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl)ethyl]-2-benzofuran-1(3H)-one

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 0 ℃; for 3h;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1428477-32-0
5-[2-(4-fluoro-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl)ethyl]-2-benzofuran-1(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: hydrogenchloride / 1,4-dioxane / 48 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 5 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 5 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl ammonium fluoride; triphenylphosphine / tetrahydrofuran / 3 h / 60 °C / Inert atmosphere; Sealed tube

6.1: palladium on activated charcoal; hydrogen / ethanol / 12 h / 760.05 Torr

7.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / -78 - 0 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; diethylamino-sulfur trifluoride; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 1428478-50-5
1-(4-ethynyl-4-hydroxypiperidin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone

: 1428477-32-0
5-[2-(4-fluoro-1-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperidin-4-yl)ethyl]-2-benzofuran-1(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl ammonium fluoride; triphenylphosphine / tetrahydrofuran / 3 h / 60 °C / Inert atmosphere; Sealed tube

2: palladium on activated charcoal; hydrogen / ethanol / 12 h / 760.05 Torr

3: diethylamino-sulfur trifluoride / dichloromethane / 3 h / -78 - 0 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; diethylamino-sulfur trifluoride; palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane;