diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

Base Information

Chemical Name:diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate
CAS No.:1428526-64-0
Molecular Formula:C₂₆H₂₆N₅O₅P
Molecular Weight:519.497
Hs Code.:

Synonyms:diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

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Chemical Property of diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

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Technology Process of diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

There total 11 articles about diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1187992-93-3
4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxylic acid

: 1428526-19-5
C₂₂H₃₀NO₅P

: 1428526-64-0
diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

Guidance literature:: With triethylamine; HATU; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 1187992-93-3
4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxylic acid

: 1428526-21-9
diethyl 4-(amino(phenyl)methyl)phenylphosphonate

: 1428526-64-0
diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

Guidance literature:: With triethylamine; HATU; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 90-90-4
(4-bromophenyl)(phenyl)methanone

: 1428526-64-0
diethyl 4-((4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 24 h / 185 °C

2.1: potassium hydroxide / methanol / 8 h / Reflux

3.1: triethylamine / dichloromethane / 0 °C

3.2: 20 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / toluene / Reflux

5.1: triethylamine; HATU / acetonitrile / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; HATU; potassium hydroxide; In methanol; dichloromethane; toluene; acetonitrile;