Chemical Property of 4-Chlorokynurenine
Chemical Property:
- Vapor Pressure:1.74E-11mmHg at 25°C
- Boiling Point:516.3°C at 760 mmHg
- Flash Point:266.1°C
- PSA：106.41000
- Density:1.454g/cm3
- LogP:2.18840
- Storage Temp.:Refrigerator
- Solubility.:Aqueous Acid (Slightly), DMSO (Sparingly)
- XLogP3:-1.6
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:4
- Exact Mass:242.0458199
- Heavy Atom Count:16
- Complexity:285
- Purity/Quality:
-
99% *data from raw suppliers
4-ChloroKynurenine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC(=C(C=C1Cl)N)C(=O)CC(C(=O)O)N
- Recent ClinicalTrials:Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive Disorder
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Uses
7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. ?Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.
