1,1-dimethylethyl 4-[N-(2-benzyloxycarbonylphenyl)aminocarbonyl]-3,5-dibenzyloxybenzoate

Base Information

• Chemical Name: 1,1-dimethylethyl 4-[N-(2-benzyloxycarbonylphenyl)aminocarbonyl]-3,5-dibenzyloxybenzoate
• CAS No.: 440105-02-2
• Molecular Formula: C₄₀H₃₇NO₇
• Molecular Weight: 643.736
• Mol file: 440105-02-2.mol

Synonyms:1,1-dimethylethyl 4-[N-(2-benzyloxycarbonylphenyl)aminocarbonyl]-3,5-dibenzyloxybenzoate

Chemical Property of 1,1-dimethylethyl 4-[N-(2-benzyloxycarbonylphenyl)aminocarbonyl]-3,5-dibenzyloxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl 4-[N-(2-benzyloxycarbonylphenyl)aminocarbonyl]-3,5-dibenzyloxybenzoate

There total 2 articles about 1,1-dimethylethyl 4-[N-(2-benzyloxycarbonylphenyl)aminocarbonyl]-3,5-dibenzyloxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl anthranilate (82185-41-9) + 3,5-Bis-benzyloxy-4-chlorocarbonyl-benzoic acid tert-butyl ester (158980-58-6) → 1,1-dimethylethyl 4-[N-(2-benzyloxycarbonylphenyl)aminocarbonyl]-3,5-dibenzyloxybenzoate (440105-02-2)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 96h;

DOI:10.1021/jm020018f

Reference yield:

2,6-bis(benzyloxy)-4-<(1,1-dimethylethoxy)carbonyl>benzoic acid (158980-56-4) → 1,1-dimethylethyl 4-[N-(2-benzyloxycarbonylphenyl)aminocarbonyl]-3,5-dibenzyloxybenzoate (440105-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂; dimethylformamide / 3 h / 20 °C

2: iPr₂NEt; DMAP / CH₂Cl₂ / 96 h / 20 °C

With dmap; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm020018f

Reference yield:

1,1-dimethylethyl 4-[N-(2-benzyloxycarbonylphenyl)aminocarbonyl]-3,5-dibenzyloxybenzoate (440105-02-2) → 3,5-Bis-benzyloxy-N-(2-benzyloxycarbonyl-phenyl)-terephthalamic acid (440105-21-5)

Guidance literature:

With formic acid; at 20 ℃; for 3h;

DOI:10.1021/jm020018f

upstream raw materials:

benzyl anthranilate

3,5-Bis-benzyloxy-4-chlorocarbonyl-benzoic acid tert-butyl ester

2,6-bis(benzyloxy)-4-<(1,1-dimethylethoxy)carbonyl>benzoic acid

Downstream raw materials:

3,5-Bis-benzyloxy-N-(2-benzyloxycarbonyl-phenyl)-terephthalamic acid