1-((1R,2S,3R,4R)-3-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-fluorocyclopentyl)-4-(N,N-di(tert-butyloxycarbonyl)amino)-1H-imidazo[4,5-c]pyridine

Base Information

Chemical Name:1-((1R,2S,3R,4R)-3-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-fluorocyclopentyl)-4-(N,N-di(tert-butyloxycarbonyl)amino)-1H-imidazo[4,5-c]pyridine
CAS No.:1374851-86-1
Molecular Formula:C₅₄H₆₇FN₄O₆Si₂
Molecular Weight:943.319
Hs Code.:

1-((1R,2S,3R,4R)-3-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-fluorocyclopentyl)-4-(N,N-di(tert-butyloxycarbonyl)amino)-1H-imidazo[4,5-c]pyridine

Synonyms:1-((1R,2S,3R,4R)-3-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-fluorocyclopentyl)-4-(N,N-di(tert-butyloxycarbonyl)amino)-1H-imidazo[4,5-c]pyridine

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Chemical Property of 1-((1R,2S,3R,4R)-3-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-fluorocyclopentyl)-4-(N,N-di(tert-butyloxycarbonyl)amino)-1H-imidazo[4,5-c]pyridine

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Technology Process of 1-((1R,2S,3R,4R)-3-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-fluorocyclopentyl)-4-(N,N-di(tert-butyloxycarbonyl)amino)-1H-imidazo[4,5-c]pyridine

There total 15 articles about 1-((1R,2S,3R,4R)-3-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-fluorocyclopentyl)-4-(N,N-di(tert-butyloxycarbonyl)amino)-1H-imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 934816-44-1
4-(N₆,N₆-di-tert-butyloxycarbonylamino)-imidazo[4,5-c]pyridine

: 1374851-80-5
(1S,2S,3R,4R)-3-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-fluorocyclopentanol

: 1374851-86-1
1-((1R,2S,3R,4R)-3-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-fluorocyclopentyl)-4-(N,N-di(tert-butyloxycarbonyl)amino)-1H-imidazo[4,5-c]pyridine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -40 - 60 ℃; for 24h;
DOI:10.1016/j.tet.2012.03.023

Reference yield:

: 1009810-90-5
2,3-(cyclopentylidenedioxy)-4-vinylcyclopentanol

: 1374851-86-1
1-((1R,2S,3R,4R)-3-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-fluorocyclopentyl)-4-(N,N-di(tert-butyloxycarbonyl)amino)-1H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: hydrogenchloride / methanol / 25 °C

3.1: 1H-imidazole; dmap / dichloromethane / 2 h / 0 - 20 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / -40 - 60 °C

5.1: lithium hydroxide / methanol / 2 h / 25 °C

6.1: pyridine; diethylamino-sulfur trifluoride / dichloromethane / 12 h / 20 °C / Inert atmosphere

7.1: sodium periodate; osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / methanol / 2 h / 0 °C

8.1: methanol; sodium tetrahydroborate / 1 h / 0 °C

9.1: 1H-imidazole; dmap / dichloromethane / 2 h / 0 - 20 °C

10.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 20 °C

10.2: 20 °C

11.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / -40 - 60 °C

With pyridine; 1H-imidazole; hydrogenchloride; methanol; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; diethylamino-sulfur trifluoride; di-isopropyl azodicarboxylate; water; sodium hydride; 4-methylmorpholine N-oxide; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 4.1: Mitsunobu reaction / 11.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2012.03.023

Reference yield:

: 1009810-89-2
(3aR,6aR)-3aH-spiro[cyclopenta[d][1,3]dioxole-2,1'-cyclopentan]-4(6aH)-one

: 1374851-86-1
1-((1R,2S,3R,4R)-3-(tert-butyldiphenylsilyloxy)-4-((tert-butyldiphenylsilyloxy)methyl)-2-fluorocyclopentyl)-4-(N,N-di(tert-butyloxycarbonyl)amino)-1H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 14 steps

1.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / -78 °C

1.2: 5 h / -78 °C

2.1: tetrabutyl ammonium fluoride; ammonium chloride / tetrahydrofuran; water / 0.5 h / 20 °C

3.1: methanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate / 1 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

4.2: 3 h / 0 - 20 °C

5.1: hydrogenchloride / methanol / 25 °C

6.1: 1H-imidazole; dmap / dichloromethane / 2 h / 0 - 20 °C

7.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / -40 - 60 °C

8.1: lithium hydroxide / methanol / 2 h / 25 °C

9.1: pyridine; diethylamino-sulfur trifluoride / dichloromethane / 12 h / 20 °C / Inert atmosphere

10.1: sodium periodate; osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / methanol / 2 h / 0 °C

11.1: methanol; sodium tetrahydroborate / 1 h / 0 °C

12.1: 1H-imidazole; dmap / dichloromethane / 2 h / 0 - 20 °C

13.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 20 °C

13.2: 20 °C

14.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / -40 - 60 °C

With pyridine; 1H-imidazole; hydrogenchloride; methanol; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; copper(I) bromide dimethylsulfide complex; diethylamino-sulfur trifluoride; cerium(III) chloride heptahydrate; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; sodium hydride; ammonium chloride; 4-methylmorpholine N-oxide; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 7.1: Mitsunobu reaction / 14.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2012.03.023