C₁₈H₁₂ClF₄N₃O₂

Base Information

Chemical Name:C₁₈H₁₂ClF₄N₃O₂
CAS No.:1422176-19-9
Molecular Formula:C₁₈H₁₂ClF₄N₃O₂
Molecular Weight:413.759
Hs Code.:

C<sub>18</sub>H<sub>12</sub>ClF<sub>4</sub>N<sub>3</sub>O<sub>2</sub>

Synonyms:C₁₈H₁₂ClF₄N₃O₂

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₈H₁₂ClF₄N₃O₂

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Technology Process of C₁₈H₁₂ClF₄N₃O₂

There total 8 articles about C₁₈H₁₂ClF₄N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422175-55-0
methyl 2-chloro-5-{[5-(4-fluorophenyl)-2-trifluoromethyl-3H-imidazole-4-carbonyl]amino}benzoate

: 1422176-19-9
C₁₈H₁₂ClF₄N₃O₂

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 1h;

Reference yield:

: 7292-73-1
(2RS)-N-(p-fluorophenyl)glycine

: 1422176-19-9
C₁₈H₁₂ClF₄N₃O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2 h / 20 °C

2.1: tributylphosphine / toluene / 12 h / 20 °C

3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 2585.81 Torr

4.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h

4.2: 48 h / Reflux

5.1: diisobutylaluminium hydride / dichloromethane / 1 h / -78 °C

With tributylphosphine; 5%-palladium/activated carbon; hydrogen; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane; toluene;

Reference yield:

: 6307-82-0
2-chloro-5-nitro-benzoic acid methyl ester

: 1422176-19-9
C₁₈H₁₂ClF₄N₃O₂

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(II) chloride dihdyrate; ethanol / 2 h / Sealed tube; Sonication

2.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h

2.2: 48 h / Reflux

3.1: diisobutylaluminium hydride / dichloromethane / 1 h / -78 °C

With tin(II) chloride dihdyrate; ethanol; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane;