2,6-Dichloro-4-methylaniline

Base Information

• Chemical Name: 2,6-Dichloro-4-methylaniline
• CAS No.: 56461-98-4
• Molecular Formula: C7H7 Cl2 N
• Molecular Weight: 176.045
• Hs Code.: 2921430090
• DSSTox Substance ID: DTXSID90205007
• Nikkaji Number: J549.688H
• Wikidata: Q83078498
• Mol file: 56461-98-4.mol

Synonyms:2,6-dichloro-4-toluidine

Chemical Property of 2,6-Dichloro-4-methylaniline

Chemical Property:

• Vapor Pressure: 0.03mmHg at 25°C
• Melting Point: 56-57 °C
• Boiling Point: 244.7°Cat760mmHg
• PKA: 1.14±0.10(Predicted)
• Flash Point: 101.8°C
• PSA: 26.02000
• Density: 1.334g/cm³
• LogP: 3.46520
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 174.9955546
• Heavy Atom Count: 10
• Complexity: 106

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dichloro-4-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)Cl)N)Cl

Technology Process of 2,6-Dichloro-4-methylaniline

There total 6 articles about 2,6-Dichloro-4-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-toluidine (106-49-0,12221-03-3) → 2,6-dichloro-4-methylaniline (56461-98-4)

Guidance literature:

With hydrogenchloride; dihydrogen peroxide; In methanol; for 12h; Heating;

DOI:10.1016/S0040-4039(03)00834-7

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + sulfuric acid (7664-93-9) + p-toluidine (106-49-0,12221-03-3) → 2,6-dichloro-4-methylaniline (56461-98-4) + 3-chloro-p-toluidine (95-74-9,827571-80-2) + 2-chloro-4-methyl-benzenamine (615-65-6)

Guidance literature:

Reference yield:

acetic acid-(2,6-dichloro-4-methyl-anilide) (99520-03-3) → 2,6-dichloro-4-methylaniline (56461-98-4)

Guidance literature:

With hydrogenchloride; at 100 - 120 ℃;

upstream raw materials:

1-methyl-4-nitrosobenzene

acetic acid-(2,6-dichloro-4-methyl-anilide)

4-Methylacetanilide

p-toluidine

Downstream raw materials:

3,4,5-trichloro-toluene

3,5-dichlorotoluene

4-bromo-3,5-dichloro-toluene

3,5-dichloro-4-iodo-toluene