1-((1R,2R,3S,5R)-3-Hydroxymethyl-2,6,6-trimethyl-bicyclo[3.1.1]hept-2-yl)-3-phenyl-thiourea

Base Information

Chemical Name:1-((1R,2R,3S,5R)-3-Hydroxymethyl-2,6,6-trimethyl-bicyclo[3.1.1]hept-2-yl)-3-phenyl-thiourea
CAS No.:327611-80-3
Molecular Formula:C₁₈H₂₆N₂OS
Molecular Weight:318.483
Hs Code.:

Synonyms:1-((1R,2R,3S,5R)-3-Hydroxymethyl-2,6,6-trimethyl-bicyclo[3.1.1]hept-2-yl)-3-phenyl-thiourea

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Chemical Property of 1-((1R,2R,3S,5R)-3-Hydroxymethyl-2,6,6-trimethyl-bicyclo[3.1.1]hept-2-yl)-3-phenyl-thiourea

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Technology Process of 1-((1R,2R,3S,5R)-3-Hydroxymethyl-2,6,6-trimethyl-bicyclo[3.1.1]hept-2-yl)-3-phenyl-thiourea

There total 5 articles about 1-((1R,2R,3S,5R)-3-Hydroxymethyl-2,6,6-trimethyl-bicyclo[3.1.1]hept-2-yl)-3-phenyl-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103-72-0
phenyl isothiocyanate

: 327611-76-7
(1R,2R,3S,5R)-2-amino-3-hydroxymethyl-2,6,6-trimethylbicyclo[3.1.1]heptane

: 327611-80-3
1-((1R,2R,3S,5R)-3-Hydroxymethyl-2,6,6-trimethyl-bicyclo[3.1.1]hept-2-yl)-3-phenyl-thiourea

Guidance literature:: In toluene; at 20 ℃; for 3h;
DOI:10.1016/S0957-4166(00)00435-3

Reference yield:

: 705949-02-6
C₁₂H₂₁NO₂

: 327611-80-3
1-((1R,2R,3S,5R)-3-Hydroxymethyl-2,6,6-trimethyl-bicyclo[3.1.1]hept-2-yl)-3-phenyl-thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride

2: toluene / 20 °C

With lithium aluminium tetrahydride; In toluene;
DOI:10.3390/molecules191015918

Reference yield:

: 7785-26-4,25766-18-1
(-)-α-pinene

: 327611-80-3
1-((1R,2R,3S,5R)-3-Hydroxymethyl-2,6,6-trimethyl-bicyclo[3.1.1]hept-2-yl)-3-phenyl-thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 1 h

2: 10 percent HCl / 12 h / Heating

3: LiAlH₄ / tetrahydrofuran / 2 h / Heating

4: toluene / 3 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1016/S0957-4166(00)00435-3